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Research ArticleSymposium Papers

The Purpose, Composition, and Function of an Institutional Review Board: Balancing Priorities

Kyle B Enfield and Jonathon D Truwit
Respiratory Care October 2008, 53 (10) 1330-1336;
Kyle B Enfield
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia
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Jonathon D Truwit
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia
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Abstract

The institutional review board (IRB) is one part of the research enterprise designated to protect human subjects. At times the IRB can feel like an oppressive oversight body bound by regulations and designed to inhibit research. However, in reality the IRB was an attempt by the federal government to streamline a variety of processes to ensure the protection of human subjects. Growing out of a history of unethical scientific research, the principle goal of the IRB is to protect human subjects. At some institutions the IRB has an additional role, to take a second look at proposed scientific methods to ensure the highest quality research. The legal basis, purpose, composition, and function of an IRB, and potential challenges in human-subjects research are reviewed here.

  • institutional review board
  • IRB
  • Common Rule
  • federal law
  • research ethics

Footnotes

  • Correspondence: Jonathon D Truwit MD, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia Health System, PO Box 800546, Charlottesville VA 22908;, Email: truwit{at}virginia.edu.
  • Dr Truwit presented a version of this paper at the RESPIRATORY CARE Journal Symposium at the 53rd International Respiratory Congress of the American Association for Respiratory Care, held December 1-4, 2007, in Orlando, Florida.

  • The authors report no conflict of interest related to the content of this paper.

  • Copyright © 2008 by Daedalus Enterprises Inc.
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Respiratory Care: 53 (10)
Respiratory Care
Vol. 53, Issue 10
1 Oct 2008
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The Purpose, Composition, and Function of an Institutional Review Board: Balancing Priorities
Kyle B Enfield, Jonathon D Truwit
Respiratory Care Oct 2008, 53 (10) 1330-1336;

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The Purpose, Composition, and Function of an Institutional Review Board: Balancing Priorities
Kyle B Enfield, Jonathon D Truwit
Respiratory Care Oct 2008, 53 (10) 1330-1336;
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  • institutional review board
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  • Common Rule
  • federal law
  • research ethics

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