Abstract
Palliative care is an essential component of comprehensive care for all patients with chronic critical illness, including those receiving restorative or life-sustaining therapies. Core elements include alleviation of symptom distress, communication about care goals, alignment of treatment with the patient's values and preferences, transitional planning, and family support. Here we address strategies for assessment and management of symptoms, including pain, dyspnea, and depression, and for assisting patients to communicate while endotracheally intubated. We also discuss approaches to optimize communication among clinicians, patients, and families about care goals. Challenges for supporting families and planning for transitions between care settings are identified, while the value of interdisciplinary input is emphasized. We review “consultative” and “integrative” models for integrating palliative care and restorative critical care. Finally, we highlight key ethical issues that arise in the care of chronically critically ill patients and their families.
Introduction
Palliative care is both a medical specialty and an approach to patient care that focuses on the following core elements: alleviation of symptom distress; communication about care goals; alignment of treatment with the patient's values and preferences; transitional planning; and support for both patient and family throughout the illness trajectory. Increasingly, this type of care is seen as an essential component of comprehensive care for all patients with critical illness, including those receiving restorative or life-sustaining therapies.1–3 As critical illness enters the chronic phase, close attention to palliative care principles is a paramount responsibility for all clinicians on the treatment team. Accumulating evidence suggests that early integration of palliative care can enhance the effectiveness of disease-directed treatment for patients with serious and complex illness,4,5 while improving the quality of their lives, supporting their families, and promoting efficient use of expensive resources.4,6,7 In this article we address needs, challenges, and strategies for palliative care during chronic critical illness (CCI).
Symptom Assessment and Management
Symptom distress is such a common experience for chronically critically ill patients, it has been included as a defining feature of the syndrome of CCI.8 In a prospective study of patients treated in a respiratory care unit of an acute care hospital after elective tracheotomy for failure to wean from mechanical ventilation in the ICU, three fourths of those who could self-report symptoms in real time experienced ≥ 10 of 16 symptoms included in the assessment tool (modified from the Condensed Form of the Memorial Symptom Assessment Scale).9 Over 40% of the patients reported pain at the highest levels on the scale, and more than 60% reported psychological symptoms (sadness, worry, and nervousness) “frequently” or “almost constantly.” Other physical symptoms including unsatisfied thirst and dyspnea (on full ventilator support as well as during weaning) also caused substantial distress for many patients. Approximately 90% of patients reported maximal distress due to difficulty communicating as a result of endotracheal intubation.
Jubran et al subsequently conducted a prospective study of almost 500 patients transferred to a long-term acute care facility for weaning from prolonged mechanical ventilation.10 Of 336 patients who could be evaluated, over 40% met criteria for a depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders IV.11 Duration of mechanical ventilation was twice as long for depressed patients, and they were 3 times more likely to remain ventilator dependent than those without a depressive disorder. Patients with depression were also more than twice as likely to die in the facility as those without depression, and this increased rate of mortality remained substantial after controlling for age, comorbid illness, and other independent predictors of death. These data add to a growing body of evidence associating physical and emotional symptom distress with unfavorable outcomes, while associating regular assessment and effective management of symptoms with shorter duration of mechanical ventilation and other favorable results.12–14
Given the prevalence, intensity, and broader implications of distressing symptoms among chronically critically patients, optimal care of these patients must address their comfort needs systematically and effectively. Systematic symptom assessment is an essential first step, but can be challenging when patients are impaired by brain dysfunction and inability to communicate, as is so common during CCI.15 Many patients are able to provide self-reports of their symptoms,9 which remain the gold standard for symptom assessment. For this purpose, the evaluative tool must be short and simple, like the Condensed Form of the Memorial Symptom Assessment Scale16 or Edmonton Symptom Assessment Scale,17 measuring a diverse group of symptoms, or an abbreviated instrument focused on a specific symptom such as pain, dyspnea, or depression.18–20 Several tools are available to assess symptoms such as pain and dyspnea among patients who cannot self-report (eg, Behavioral Pain Scale,21 Critical Care Pain Observation Tool,22 Assume Pain Present approach,23 and Respiratory Distress Observation Scale24), although use in chronically critically ill patients has not, to our knowledge, been reported.
To date, no published studies have evaluated interventions to alleviate symptoms in the specific context of CCI. Even in acute critical illness, scant evidence from rigorous research is available to inform symptom management, and distinctive features of CCI may limit generalizability of data from the ICU. However, studies in other seriously ill patient groups, expert recommendations, and clinical experience with the chronically critically ill support several key principles for effective symptom management. First, symptoms in this population are best addressed in the context of a comprehensive assessment because they may be exacerbated by positional, procedural, spiritual, social, and psychological factors that need concomitant attention. Second, most patients have multiple symptoms, and there may be interactions among these symptoms and among their treatments. Third, given the risks associated with polypharmacy in this patient group, “n of 1” trials of non-pharmacologic approaches, including complementary and alternative interventions,25,26 should be explored early in suitable and receptive patients.
For moderate to severe pain during CCI, clinical experience supports the preferential use of opioids as the safest and most effective class of medications. When renal function is impaired, as is common among the chronically critically ill, hydromorphone may be a better choice than morphine, which has active metabolites that accumulate and can cause prolonged sedation27 and neuronal excitation.28 Fentanyl can be administered by several alternative routes, including bolus intravenous dosing for short-acting analgesia during painful procedures (eg, care of deep pressure ulcers), and transdermal fentanyl for continuous opioid analgesia without intravenous access. Knowledge of equi-analgesic opioid dosing is important; this information is readily incorporated in computer-based ordering systems and/or on pocket cards for clinicians.29 For dyspnea, non-pharmacologic approaches such as use of a fan, relaxation, or meditation techniques, or pursed lip breathing may be helpful.30 Opioids are also effective in treating dyspnea, usually at much lower doses than are used to treat pain. Tolerance to side effects of opioid treatment, such as excessive sedation, tends to develop more quickly than tolerance to the primary treatment effect, but may require specific therapeutic strategies that have been described previously.31,32
Multiple techniques and tools at different levels of complexity and sophistication are available to assist endotracheally intubated patients to communicate.33 Some chronically critically ill patients tolerate placement of a tracheostomy speaking valve, allowing them to speak intelligibly with staff and family.34 To supplement speech (or provide a sole avenue of communication for those who cannot vocalize through a speaking valve), patients may be offered an alphabet board or a communication board, to which either they or a caregiver (with affirmation from the patient through nodding or other signaling) can point.33 Other options to enhance communication include touch screens and specialized key pads that can translate minimal physical pressure into synthesized speech, but the cost of such devices may limit their availability.33 Although many chronically critically ill patients may be too debilitated or delirious to make use of any of these methods, clinicians should make every effort to facilitate communication, given its importance to patients and their caregivers. When successful, as has been reported in case series,33,34 such efforts not only address one of the most important sources of symptom distress during CCI, but may enable patients to provide self-reports of their experience to clinicians, express their emotions and thoughts to loved ones, and participate in discussions of treatment goals and preferences.
Rigorous data are lacking to guide treatment of depression in the specific context of CCI. In our clinical experience, appreciation of both the patient's prognosis (for survival and/or ventilator liberation) and prior psychiatric history can be helpful in choosing the most appropriate treatments (pharmacologic and/or non-pharmacologic). Selective serotonin reuptake inhibitors are well tolerated by these patients, but response latency may be too long to improve mood or energy during initial weeks of weaning efforts. For more rapid onset of action, we have had success with the use of psychostimulants such as methylphenidate at low doses, without untoward effects.35,36 A consultant with psychopharmacology expertise may be helpful in selecting adjunctive therapies in this patient population.25
Communication About Care Goals
Communication about care goals in the context of CCI is often complicated for several reasons. First, the patient's very survival of the acute phase of critical illness may give the family unfounded hope for a meaningful recovery. Qualitative research suggests that families often misperceive the placement of tracheotomy as a sign that the patient is progressing toward ventilator liberation and eventual recovery.37 Second, since most patients move to one or more different care settings for the chronic phase of their illness,38 ICU clinicians may themselves fail to appreciate the high risks of mortality and severe morbidity after ICU discharge,39 or may choose to defer communication about these risks.39 Third, fragmentation and discontinuity of care tend to increase as critical illness continues over a prolonged period, creating obstacles to coordinated, consistent communication.
Critical care guidelines endorse a shared decision-making model in which both the patient and the clinician play an active role,40 but there is a wide continuum of preferred roles in decision making among patients and families, and clinicians need to be flexible to facilitate decisions that are most consistent with the patient's values and preferences.41 Chronically critically ill patients are usually unable to participate directly in communication and decision-making,15 and few have formally designated a surrogate decision-maker or prepared another advance directive.42 Thus, discussions and decision-making about goals of care usually involve the patient's family or other surrogates, who may lack sufficient knowledge of the patient's preferences43 or who may be burdened by psychological or practical issues44 that serve as barriers to patient-focused decision making.
Goals of care are ideally determined through a series of proactive, sensitive, and structured discussions in which the patient and/or surrogates receive information about the nature and prognosis of the illness, and consensus is achieved on therapeutic options that are consistent with the patient's values and preferences. These goals of care may shift in relation to observed effect of restorative treatment, but such shifts are difficult to make abruptly. In our experience, a slower, incremental approach, proceeding with patience over a series of discussions, is ultimately more effective and efficient in achieving consensus. Contributions from multiple members of the interdisciplinary team are helpful in meeting the challenges of this type of communication. The role of the patient's nurse in ICU family meetings has recently been highlighted,45 and extends into the chronic phase of critical illness. As reviewed more fully elsewhere, active participation by the nurse in discussions about goals of care is appropriate and important for many reasons.45,46 Involvement of other disciplines, such as social work, chaplaincy, and respiratory therapy, and engagement of palliative care and/or ethics consultants, can also enhance communication with families of the chronically critically ill. To ensure that input from all members of the interdisciplinary team is integrated and that a consistent approach is taken with the family, the team should always “pre-meet” themselves before a family meeting and discuss the family meeting after in a debriefing session. In addition, key information exchanged during the family meeting should be documented in the medical record so that all members of the team understand the status of ongoing communications with the family.
Qualitative investigation of ICU family conferences suggests specific skills and approaches that may improve the efficacy of communication by clinicians. Whereas physicians tend to dominate discussions with families, this research indicates the importance of listening47: family satisfaction has been associated with the proportion of time the family speaks in these meetings, relative to the time in which clinicians are speaking to the family. An effective approach to encourage comments and questions from family members is summarized as “Ask, Tell, Ask.”48 The clinician begins the discussion by asking family members to report their understanding of a situation (eg, the patient's condition and prognosis), and by asking permission to continue with the discussion. The clinician then provides a succinct update of the situation in layperson's terms. The family is then asked again to summarize the discussion, comment, and ask questions.
Studies in the ICU and other settings indicate that physicians frequently miss opportunities to acknowledge and address the family's emotions.49,50 Families are more satisfied, however, when their emotions are explicitly addressed by clinicians. In addition, strong emotions can overwhelm the ability to absorb and integrate information needed for rational decision-making.51 Thus, communication should incorporate expressions of empathy, which help to modulate emotional fluctuation and distraction.52 The acronym NURSE has been suggested to summarize statements that communicate empathy explicitly: Name the emotion to make clear that it is recognized; express Understanding in an open and compassionate way; show Respect for the person experiencing the emotion; communicate Support; and Explore the emotional experience of the other person in greater depth (Table 1).53
When communication addresses limitation of life support, research suggests that families are more satisfied when clinicians provide assurance that the patient will not be abandoned prior to death and will not suffer, and support the family's decision whether to forgo or continue the therapy.54 Expert recommendations have been provided for approaching patients and family members who prefer continuation of life-supporting treatments based on the belief that a miracle will occur,55 and those who insist on “everything” despite a clinician's view that the treatments will not have meaningful benefit.56 Communication of prognostic information is particularly challenging. Most family decision-makers and other surrogates lack knowledge of the nature and expected outcomes of CCI, but consider this information important.37,39,57 In one study, for example, the vast majority of surrogates for chronically critically ill patients with recent tracheotomy reported that they received no information about possible functional dependence at discharge or about prognosis for 1-year survival, respectively.57 In another study, Cox et al found that families were far more optimistic than their physicians about long-term outcomes for patients on prolonged mechanical ventilation.39 Over 90% of families expected the patient to survive for at least a year (compared to 44% of the physicians), and more than 70% of families anticipated no major functional impairment (compared to 6% of the physicians).39 This discordance of expectations suggested that communication between physicians and families could be improved.39 Other factors contributing to overestimation of prognosis by families include health optimism, intuition, and overriding faith in God.58,59 Exploration of such factors may help the clinician to provide prognostic information and support decision-making in more meaningful and appropriate ways. Again, attention to family emotions is essential in enhancing the capacity of the family to hear and act upon information communicated by clinicians.
Several tools have recently become available to support effective and efficient communication with families of the critically ill. First, a new prognostic model, “ProVent,” uses 4 easily collected variables (age, platelet count, and use of vasopressors and hemodialysis) to estimate 1-year survival of patients requiring prolonged mechanical ventilation.60 This simple model, which has been validated in multiple centers, can help inform discussions of the risk of mortality for the chronically critically ill patient, although more research is needed to guide effective incorporation of such information in a broader discussion of appropriate goals of care. Second, a brochure for families about CCI, which was developed and validated with sponsorship from the National Institutes of Health Clinical Center's Department of Bioethics, and from the Patient and Family Support Committee of the Society of Critical Care Medicine, is available.61 This brochure uses a question-and-answer format to address issues including: What is CCI? What treatment is available? Do chronically critically ill patients regain the ability to breathe on their own? Can patients with CCI live on their own? What is the experience like for families? What is a tracheotomy? and What are the options? An ongoing randomized controlled, multicenter trial funded by the National Institutes of Health is evaluating the impact on family well-being and other outcomes of this brochure along with protocol-guided family meetings led by palliative care specialists, compared to the brochure with usual care. The value of printed informational materials for educating families of ICU patients has previously been shown in rigorous studies.62,63 In addition, a Family Meeting Guide can be given to families to help them prepare for an upcoming discussion.64,65 This guide encourages families to gather relevant information and materials, focus on specific topics (examples are provided), and write down questions for clinicians.
A variety of templates for physician documentation of family meetings are available for use or adaptation to meet local needs.66 Such templates can enhance efficiency, and, if key topics for discussion are included, can also provide a framework for the meeting. Proper documentation of the family meeting also supports appropriate physician reimbursement. If the patient is critically ill or injured, the critical care codes 99291 and 99292 allow physicians to report time spent in meetings with surrogates under the following circumstances: the patient lacks capacity to participate directly in the discussion and decision-making, and the discussion is necessary for decision-making about medical treatment.67 For the purposes of these codes, critical care time would thus include properly documented discussions about use or limitation of cardiopulmonary resuscitation (ie, whether to attempt resuscitation or not attempt resuscitation in the event of an arrest), and discussions in connection with medical decision-making about use or limitation of other treatments such as mechanical ventilation, renal replacement therapy, and artificial nutrition and hydration. In addition, if the patient has capacity to participate, communication with the patient's family or other surrogate decision-maker can still be reported as critical care time under these codes, provided that the patient is present for the discussion and treatment options are discussed.67
Family Support and Transition Planning
As critical illness becomes chronic, the emotional, physical, and practical burdens for families weigh heavily. On average, the length of the acute hospital stay for chronically critically ill patients is 2 months, and hospital survivors spend 75% of their days during the year after their illness in institutional care or with paid home assistance.38 Families' personal and professional lives are often substantially disrupted during this time.68–70 A study by Swoboda and Lipsett found that most families of patients with prolonged surgical illness were providing assistance throughout the year after the illness, often leaving their paid employment and depleting their savings.68 Others have reported similar findings for families of patients on prolonged mechanical ventilation during medical or surgical illness or after trauma.69 Like informal caregivers for other patients with chronic illness,71 those caring for the chronically critically ill experience substantial decrements in physical health as well as role overload and burden that accumulate over time.72 Depression is highly prevalent among these families, and multiple studies suggest that depression is more severe for those whose loved ones are institutionalized than for those caring for patients at home.73,74 Acute and post-traumatic stress symptoms affect families of patients surviving acute critical illness,75–77 and in light of evidence suggesting that symptoms of post-traumatic stress disorder increase over time for these families,77,78 it is likely that families of the chronically critically ill are also affected.79 In follow-up interviews with bereaved family members of patients who died in the ICU, one third met Diagnostic and Statistical Manual of Mental Disorders-IV criteria for at least one psychiatric disorder (major depression, generalized anxiety, panic, or complicated grief).80
Interdisciplinary support and transitional planning are important for families of the chronically critically ill, although models for delivering this care need further investigation. Douglas et al evaluated a disease management program for patients with prolonged mechanical ventilation (median duration of mechanical ventilation was 8 d) and their families.81,82 The 8-week intervention was implemented in a single center by an advanced practice nurse who provided emotional support, care coordination, education, and case management services to the patient and the caregiver before and after hospital discharge. Compared to usual care, this intervention was not associated either with lower rates of readmission for these patients or with lower depression, burden, or physical health among caregivers. The effect of a structured communication and support intervention from a palliative care physician and nurse, with optional participation by the critical care physician, is currently being studied in a randomized controlled trial (NCT 01230099 ClinicalTrials.gov) enrolling patients who have been mechanically ventilated for ≥ 7 days and are not expected to wean or to die in the near future. Outcomes of this study include psychological well-being of the patient's family or other surrogate medical decision-maker. While the results of ongoing and future research are awaited, clinicians are encouraged to engage an interdisciplinary team to address families' emotional, spiritual, and practical needs. Support for family members enables them to function more effectively as caregivers and surrogate decision-makers, thereby benefiting patients and clinicians as well as themselves.
Models for Integrating Palliative Care and Restorative Critical Care for the Chronically Critically Ill
For integrating and improving palliative care in the ICU, 3 main models have been described: the “consultative model” relies primarily on palliative care specialists; the “integrative model” builds on the internal capability of the clinical team to provide palliative care; and a third model combines features of the other two.83 Each of these models has advantages and disadvantages, as reviewed previously.83 At the present time, palliative care consultants are available in the majority of acute care hospitals, and their presence is increasing.84 Availability in long-term facilities is more limited, but expanding.85 Given the special challenges of managing symptoms, communicating about goals of care, supporting families, and planning transitions in the context of CCI, the expertise of specialists in palliative care may be especially valuable. Many palliative care teams have mechanisms in place to facilitate bereavement and other support for families. At the same time, clinicians and other healthcare providers for chronically critically ill patients and their families require basic palliative care knowledge and skills. Choice of the optimal model should be determined by local needs and resources at the individual institution.83
Ethical Issues
Important ethical issues arise in the care of the chronically critically ill.86 The most difficult dilemma is a societal one: how to provide optimal care for these patients in light of the poor prognosis for so many and the high costs in both human and economic terms. As the number of patients with CCI increases and the costs of their care continue to rise, this question will loom larger. Further research and public education are needed to address it. The role of the family or other surrogates in medical decision-making can create an ethical challenge if they weigh their own needs and concerns against the values and best interests of the patients for whom they have decisional responsibility. The ethical mandate of the surrogate, as currently defined, is to follow the patient's wishes previously expressed when the patient was competent, and, when these are not clear (as is most often the case), to apply “substituted judgment” of the patient or decide in the patient's best interest.87 However, the actual or perceived impact of CCI on the lives and well-being of families can bias the surrogate's perspective and impede patient-focused decision-making.44 Clinicians should monitor interactions with surrogates for evidence of conflicting interests and maintain the primacy of the patient's interest, engaging assistance of ethics and/or palliative care experts as needed. Another ethical issue is presented when clinicians face requests for interventions that to them seem futile—that is, not reasonably expected to accomplish an appropriate medical goal. Ideally, this issue is avoided through effective communication between the clinician and the patient or family to establish a mutually acceptable plan of care.88 Proactive ethics consultation has been studied as a means to improve communication and resolve such conflicts in the ICU setting,89 but has not been systematically evaluated in the chronically critically ill patient population. In many institutions, palliative care consultants are also available to assist in these discussions. Whether or not consensus can be achieved, the clinician is ultimately obligated to weigh the potential benefits and risks of each intervention in the exercise of professional judgment. Except as required by law, clinicians need not defer to patient or family demands for treatment imposing excessive burden in relation to expected benefit, but should explain their reasoning with clarity and sensitivity.
Summary
The majority of chronically critically ill patients are dead within 6 months: a mortality rate exceeding that for most malignancies. For most survivors, severe functional dependence persists, and impairments of cognitive function are common and profound. Few return to the community, and, in the year following the acute hospitalization, 75% of days for survivors of CCI are spent in institutional care or receiving paid home care, with multiple transitions across care settings. The impact on families is often devastating. It is difficult to imagine a group of patients with greater need for high-quality palliative care. Increasing evidence indicates that integration of palliative care with disease-directed care during serious illness, including acute and chronic critical illness, is beneficial for patients, families, clinicians, and the healthcare system. Further research to inform this care in the specific context of CCI deserves high priority from investigators and funders.
Discussion
MacIntyre:
You focused, and I understand why, on the physician-patient relationship. In my experience, it's important to have the entire team on board here. You have nurses who are with the patient 24 hours a day, and RTs [respiratory therapists] and physical therapists at the bedside a lot. I think it's critical that all of them are saying the same thing, or you can have a wonderful physician-patient-surrogate discussion, only to have the nurse say something completely different.
Nelson:
I'm really glad you brought that up, Neil, because the entire interdisciplinary team is crucial. The nurses in particular have a huge role in this communication process. One factor is that the nurse is at the bedside more than anybody else, and, in a fragmented system, hears disparate communications between patients and families and various clinicians. Usually the nurse has an excellent relationship with the family and an understanding of both the medical information and the patient and family.
We have been training nurses in communication skills, with the belief that, as part of an interdisciplinary team, nurses can be active and very effective participants in discussions with patients and their surrogates. We've been doing that in the Veterans Affairs system and the Voluntary Hospital Association. There are also chaplains, RTs, and others.
MacIntyre:
Since this is respiratory focus, in my institution the families like to ask the RTs, because they are presumed to be the ventilator experts—where this ventilator management is going and what it's doing. It's important that they're saying the same thing, too.
Nelson:
Correct. Ideally the communication is integrated, because otherwise patients or families may take a fragment out of context.
Snyder:*
With that respiratory focus, I'd like to highlight something you said, and I'm very glad you said it. In several of our hospitals we use speaking valves, and for the staff, the physicians, the RTs, and especially the families who get that chance to hear their loved one communicate, it is very heartwarming and there are tears. It's very uplifting, not only for the family, but for the staff as well, so I'm really glad you highlighted that. It's really a game-changer in people's treatment plans.
Nelson:
I agree, and I think the RTs are essential in making that happen in a safe and effective way. We were also very impressed by the impact of this.
Mechanick:
I want to repeat a question you mentioned to me after my presentation, which was, despite all the rhetoric and technological advances, why have we not made more progress? You would think that with all of this sophisticated intervention, every patient should be liberated from the ventilator. The point is that, in theory, this process is very complicated and there are many other factors and most likely a threshold phenomenon. With that in mind, I want to offer to you that, just because you have something a little “softer,” such as symptom burdens and palliative care, than “hard science”—and I'm using those terms in quotes, as extremes, it isn't pejorative—that does not mean that the two paradigms cannot be coordinated. It turns out that scientifically defined events like allostatic load are still affected by less-defined events, like having a pet or family or music at the bedside, or changing the light/dark cycle. These events are all scientifically and evidence-based to some degree, and certainly approaching symptom burden and palliation are going to act within gray areas to restore a normal, low-stress allostatic state and have as good an impact on recovery as anything as sophisticated as discrete metabolic interventions or antibiotics.
Nelson:
I think the days are long gone when we could look at palliative care as a soft, fuzzy area. It's a medical specialty, it's an area of scientific research, and it's a highly effective form of treatment when integrated with others.
Footnotes
- Correspondence: Judith E Nelson MD JD, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1232, New York NY 10029. E-mail: judith.nelson{at}mssm.edu.
Dr Nelson presented a version of this paper at the 49th Respiratory Care Journal Conference, “The Chronically Critically Ill Patient,” held September 9–10, 2011, in St Petersburg, Florida.
Dr Nelson was partly supported by Academic Career Leadership Award K07-AG034234 from the National Institute on Aging. The authors have disclosed no conflicts of interest.
↵* Lisa Snyder MD MPH, Select Medical, Mechanicsburg, Pennsylvania.
- Copyright © 2012 by Daedalus Enterprises Inc.
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