BACKGROUND: Mechanical ventilation is necessary in diverse clinical circumstances. Especially in the context of ARDS, so-called protective ventilation strategies must be followed. It is already known that PEEP might enhance oxygenation in ARDS. However, determining the optimal PEEP settings in clinical routines is challenging. Electrical impedance tomography (EIT) is a promising technique with which to adjust ventilator settings. We investigated whether the combination of different EIT parameters, namely the global inhomogeneity and hyperdistension indices, may lead to a feasible and safe PEEP setting.
METHODS: ARDS was induced by a double-hit approach in 18 pigs weighing, on average, 34.8 ± 3.97 kg. First, a surfactant washout was conducted; second, the tidal volume was increased to 20 mL/kg body weight, triggering a ventilator-induced lung injury. Subsequently, pigs were randomized to either the EIT or control groups, followed by an observation time of 24 h. In the control group, PEEP was set according to the ARDS network table. In the EIT group, a PEEP trial was conducted to determine an appropriate PEEP. At defined time points, hemodynamic measures, ventilation parameters, and EIT recordings, as well as blood samples, were taken. After euthanization, lungs were removed for subsequent histopathological and cytological examination.
RESULTS: The combination of PEEP and FIO2 differed between groups, although respiratory compliance, gas exchange, and histopathological examinations, as well as hemodynamics, did not show any statistical differences between the EIT and control groups. However, in the control group, the PEEP/FIO2 settings followed the given coupling; in the EIT group, divergent individual combinations of PEEP and FIO2 ranges occurred.
CONCLUSIONS: PEEP setting by EIT facilitates a more individual ventilation therapy. However, in our relatively short ARDS observation period of 24 h, no significant differences appeared in common clinical parameters compared with a control group.
- individualized mechanical ventilation
- double-hit animal model of ARDS
- electrical impedance tomography
- global inhomogeneity index
- hyperdistension index
- Correspondence: Michael Czaplik MD, Department of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. E-mail: .
Dr Czaplik was funded by grants from the Medical Faculty of RWTH Aachen University (“START”, “Rotationsstelle”). Prof Leonhardt and Dr Czaplik have disclosed relationships with Dräger Medical GmbH (Lübeck, Germany). Prof Rossaint has disclosed relationships with CSL Behring, Bayer Healthcare, and Ingelheim Boehringer. The other authors have disclosed no conflicts of interest.
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