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Research ArticleOriginal Research

Bioavailability of Beclometasone From Two HFA-BDP Formulations With a Spacer

Amira SA Said, Salahdein AbuRuz and Henry Chrystyn
Respiratory Care October 2019, 64 (10) 1222-1230; DOI: https://doi.org/10.4187/respcare.06689
Amira SA Said
Clinical Pharmacy Department, College of Pharmacy, Al Ain University of Science and Technology, Al Ain, United Arab Emirates.
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Salahdein AbuRuz
Clinical Pharmacy Department, College of Pharmacy, Al Ain University of Science and Technology, Al Ain, United Arab Emirates.
Department of Clinical Pharmacy, College of Pharmacy, Al Ain University of Science and Technology, Al Ain, United Arab Emirates; Department of Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman.
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Henry Chrystyn
Inhalation Consultancy Limited, Leeds, United Kingdom.
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    Fig. 1.

    Mean (SD) 30-min urinary amounts of BDP excreted after inhalation of 8 doses of BDP from Qvar Easi-Breathe (100 μg) and Clenil metered-dose inhaler (250 μg), with and without spacer (both rinsed and unrinsed). BDP = beclometasone dipropionate.

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    Fig. 2.

    Mean (SD) 24-h urinary amounts of BDP excreted after inhalation of 8 doses of BDP from Qvar Easi-Breathe (100 μg) and Clenil metered-dose inhaler (250 μg), with and without spacer (both rinsed and unrinsed). BDP = beclometasone dipropionate.

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Respiratory Care: 64 (10)
Respiratory Care
Vol. 64, Issue 10
1 Oct 2019
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Bioavailability of Beclometasone From Two HFA-BDP Formulations With a Spacer
Amira SA Said, Salahdein AbuRuz, Henry Chrystyn
Respiratory Care Oct 2019, 64 (10) 1222-1230; DOI: 10.4187/respcare.06689

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Bioavailability of Beclometasone From Two HFA-BDP Formulations With a Spacer
Amira SA Said, Salahdein AbuRuz, Henry Chrystyn
Respiratory Care Oct 2019, 64 (10) 1222-1230; DOI: 10.4187/respcare.06689
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Keywords

  • beclometasone dipropionate
  • urinary excretion
  • inhalation
  • spacers
  • relative lung bioavailability

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