Skip to main content
 

Main menu

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Coming Next Month
    • Archives
    • Top 10 Papers in 2020
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • Call for Abstracts 2021
    • 2020 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语

User menu

  • Subscribe
  • My alerts
  • Log in

Search

  • Advanced search
American Association for Respiratory Care
  • Subscribe
  • My alerts
  • Log in
American Association for Respiratory Care

Advanced Search

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Coming Next Month
    • Archives
    • Top 10 Papers in 2020
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • Call for Abstracts 2021
    • 2020 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语
  • Follow aarc on Twitter
  • Visit aarc on Facebook
Review ArticleSystematic Review

Frequency of Signs and Symptoms in Persons With Asthma

Zhengguang He, Juntao Feng, Junbo Xia, Qingguo Wu, Hong Yang and Qianli Ma
Respiratory Care February 2020, 65 (2) 252-264; DOI: https://doi.org/10.4187/respcare.06714
Zhengguang He
Respiratory Center of Suining Central Hospital, Sichuan, China.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Juntao Feng
Respiratory Medicine, Xiangya Hospital, Central South University, Hunan, China.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Junbo Xia
Respiratory Medicine, Hangzhou 1st People's Hospital affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Qingguo Wu
Respiratory Medicine, Zhejiang Traditional Chinese Medicine University 2nd Affiliated Hospital, Hangzhou, Zhejiang, China.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hong Yang
Respiratory Medicine, Huangdao District Traditional Chinese Medicine Hospital, Shandong, China.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Qianli Ma
Institution of Respiratory Disease, Xinqiao Hospital of 3rd Military Medical University, Chongqing, China.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • Supplemental
  • References
  • Info & Metrics
  • PDF
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

BACKGROUND: Signs and symptoms of asthma are well established; however, no study has been performed to rank them. Therefore, we performed this systematic review and meta-analysis to determine the pooled frequencies of different signs and symptoms of asthma in subjects age ≥ 14 y to develop a patient-specific questionnaire.

METHODS: Specific search queries were developed to include records published in Embase, PubMed, Cochrane Library, and Google Scholar, until November 2016. We planned to include randomized controlled trials (RCTs) and observational studies for determining the pooled proportions of signs and symptoms and association between combination of symptoms and asthma severity in subjects age ≥ 14 y. The quality assessment was performed using 3 parameters: reported number or percentage of subjects with asthma symptoms, respiratory disorder history, and method for data collection.

RESULTS: Of the 4,939 records retrieved, 67 observational studies (N = 57,033 subjects; age ≥ 14 y) were considered eligible for inclusion in the analysis. A total of 10 symptoms were reported across the studies, with pooled proportions of nasal congestion, sleep disturbances, breathlessness, chest tightness, and wheezing being 61.57%, 56.56%, 50.31%, 50.41%, and 46.97%, respectively. In records of medical history, the pooled proportion of rhinitis was 76.37%, followed by allergy/atopy at 63.53%. The pooled proportion of asthma medication use was 83.27%. In terms of the symptom combinations, the combination of wheezing, breathlessness, chest tightness, and cough was reported in 71.26% of subjects from 4 studies (n = 12,014 subjects). Nasal congestion, sleep disturbance, and chest tightness were the most common symptoms of asthma, followed by wheezing and breathlessness with a combination of symptoms (ie, wheezing, breathlessness, chest tightness, and cough) affecting the highest proportion of subjects.

CONCLUSIONS: Asthma severity was dependent on variety of symptoms, consisting mostly of wheezing, breathlessness, chest tightness, and cough. On the basis of our analysis, we recommend a combination of symptoms be included in diagnostic-based questionnaires to aid early diagnosis.

  • asthma
  • history
  • meta-analysis
  • sign
  • symptom
  • questionnaire

Footnotes

  • Correspondence: Qianli Ma PhD MD, Institution of Respiratory Disease, Xinqiao Hospital of 3rd Military Medical University, Chongqing, China. E-mail: cqmql{at}163.com.
  • The authors were supported in part by AstraZeneca. The authors have disclosed no other conflicts of interest.

  • Supplementary material related to this paper is available at http://www.rcjournal.com.

  • Copyright © 2020 by Daedalus Enterprises
View Full Text

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$15.00

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Log in using your username and password

Forgot your user name or password?
PreviousNext
Back to top

In this issue

Respiratory Care: 65 (2)
Respiratory Care
Vol. 65, Issue 2
1 Feb 2020
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Association for Respiratory Care.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Frequency of Signs and Symptoms in Persons With Asthma
(Your Name) has sent you a message from American Association for Respiratory Care
(Your Name) thought you would like to see the American Association for Respiratory Care web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Frequency of Signs and Symptoms in Persons With Asthma
Zhengguang He, Juntao Feng, Junbo Xia, Qingguo Wu, Hong Yang, Qianli Ma
Respiratory Care Feb 2020, 65 (2) 252-264; DOI: 10.4187/respcare.06714

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Frequency of Signs and Symptoms in Persons With Asthma
Zhengguang He, Juntao Feng, Junbo Xia, Qingguo Wu, Hong Yang, Qianli Ma
Respiratory Care Feb 2020, 65 (2) 252-264; DOI: 10.4187/respcare.06714
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Methods
    • Results
    • Pooled Frequencies
    • Discussion
    • Conclusions
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • References
  • PDF

Related Articles

Cited By...

Keywords

  • asthma
  • history
  • meta-analysis
  • sign
  • symptom
  • questionnaire

Info For

  • Subscribers
  • Institutions
  • Advertisers

About Us

  • About Us
  • Editorial Board
  • Reprints/Permissions

AARC

  • Membership
  • Meetings
  • Clinical Practice Guidelines

More

  • Contact Us
  • RSS
American Association for Respiratory Care

Print ISSN: 0020-1324        Online ISSN: 1943-3654

© Daedalus Enterprises, Inc.

Powered by HighWire