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Review ArticleReview

Relationship Between Medication Adherence and Health-Related Quality of Life in Subjects With COPD: A Systematic Review

Tamás Ágh, Péterné Dömötör, Zoltán Bártfai, András Inotai, Eszter Fujsz and Ágnes Mészáros
Respiratory Care September 2014, respcare.03123; DOI: https://doi.org/10.4187/respcare.03123
Tamás Ágh
Syreon Research Institute, Budapest, Hungary.
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Péterné Dömötör
Department of Pulmonology, Elisabeth Teaching Hospital and Rehabilitation Institute Sopron, Sopron, Hungary.Faculty of Economics, University of West Hungary, Sopron, Hungary.
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Zoltán Bártfai
Department of Pulmonology, Elisabeth Teaching Hospital and Rehabilitation Institute Sopron, Sopron, Hungary.
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András Inotai
Syreon Research Institute, Budapest, Hungary.
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Eszter Fujsz
Department of Pulmonology, Elisabeth Teaching Hospital and Rehabilitation Institute Sopron, Sopron, Hungary.
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Ágnes Mészáros
University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary.
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Abstract

BACKGROUND: Various aspects of medication adherence and health-related quality of life (HRQOL) have been studied in subjects with COPD. Nevertheless, little is known about the association between these factors. The aim of this study was to undertake a systematic review of the published literature focusing on the relationship between medication adherence and HRQOL in COPD.

METHODS: A systematic literature search of English language articles was conducted in April 2013 using MEDLINE. No publication date limits were defined. All of the included studies were assessed for quality.

RESULTS: Seven studies were included in the review. Three of the assessed studies found no correlation, and 3 studies described positive and 2 studies reported negative associations between medication adherence and HRQOL. The results indicate that an improved HRQOL may be a trigger for non-adherence in patients with COPD.

CONCLUSIONS: The relationship between medication adherence and HRQOL may be dual. The effect of medication adherence on HRQOL might be a consequence of the effectiveness of therapy and the negative effects (ie, side effects, daily life limitation of therapy, social stigma) that it can generate. HRQOL might also influence the patterns of patients’ drug use, as an increased HRQOL might trigger non-adherence. The dynamics between adherence and HRQOL might differ over time, as the negative effects of medication non-adherence might become dominant in the long term.

  • chronic obstructive pulmonary disease
  • COPD
  • medication adherence
  • medication compliance
  • quality of life
  • patient outcome assessment
  • respiratory therapy

Footnotes

  • Correspondence: Tamás Ágh MD PhD, Syreon Research Institute, Thököly Street 119, 1146 Budapest, Hungary. E-mail: tamas.agh{at}syreon.eu.
  • The authors have disclosed no conflicts of interest.

  • Dr Ágh and Ms Dömötör are co-first authors.

  • Copyright © 2014 by Daedalus Enterprises Inc.
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Respiratory Care: 64 (2)
Respiratory Care
Vol. 64, Issue 2
1 Feb 2019
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Relationship Between Medication Adherence and Health-Related Quality of Life in Subjects With COPD: A Systematic Review
Tamás Ágh, Péterné Dömötör, Zoltán Bártfai, András Inotai, Eszter Fujsz, Ágnes Mészáros
Respiratory Care Sep 2014, respcare.03123; DOI: 10.4187/respcare.03123

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Relationship Between Medication Adherence and Health-Related Quality of Life in Subjects With COPD: A Systematic Review
Tamás Ágh, Péterné Dömötör, Zoltán Bártfai, András Inotai, Eszter Fujsz, Ágnes Mészáros
Respiratory Care Sep 2014, respcare.03123; DOI: 10.4187/respcare.03123
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Keywords

  • chronic obstructive pulmonary disease
  • COPD
  • medication adherence
  • medication compliance
  • quality of life
  • patient outcome assessment
  • respiratory therapy

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