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BACKGROUND: A ventilator includes the function to measure flow velocity. We aimed to compare the predictive accuracy for re-intubation diagnosed by cough peak flow (CPF) measured by a spirometer and a ventilator.
METHODS: Endotracheally intubated subjects who passed a spontaneous breathing trial were enrolled. Before extubation, CPF was measured by a spirometer and a ventilator, respectively. Re-intubation was recorded at 72 h after extubation.
RESULTS: A total of 126 subjects were enrolled. Among them, 15 subjects (12%) experienced re-intubation. CPF was lower in re-intubated subjects than those without re-intubation (measured by a spirometer: 54 ± 30 L/min vs 86 ± 37 L/min, P < .001; and measured by a ventilator: 50 ± 22 L/min vs 80 ± 26 L/min, P < .001). CPF measured by a spirometer and a ventilator had similar area under the curve of receiver operating characteristic (0.79 vs 0.83, P = .26). When a CPF of 56.4 L/min was measured by a spirometer as cutoff value, the sensitivity and specificity to distinguish re-intubation was 73 and 87%, respectively. When it was measured by a ventilator, the cutoff value, sensitivity, and specificity were 56 L/min, 73%, and 85%, respectively.
CONCLUSIONS: CPF measurement by a ventilator was convenient, affordable, and safe. It had a predictive accuracy for re-intubation similar to that of a spirometer.
- Correspondence: Jun Duan MD, Department of Respiratory Medicine, First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Yuzhong District, Chongqing 400016, China. E-mail: .
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