There is a growing body of evidence, in people with cystic fibrosis, to support peripheral skeletal muscle abnormalities that may contribute to increased fatigability and reduced physical activity. This may, in turn, further exacerbate exercise intolerance and reduce health-related quality of life, the latter of which is associated with increased risks of hospitalization and poorer survival in people with cystic fibrosis (see Gruet et al1 for a review). Peripheral muscle testing in cystic fibrosis is thus relevant for both clinical and research purposes, notably for early detection and monitoring of limb muscle abnormalities, designing targeted therapies, and evaluating their effectiveness; however, at present, it is rarely used. Development and validation of suitable testing protocols for this patient group should help to increase its uptake. Ideally, a test should evaluate all components of muscle function (ie, strength, endurance, power, fatigability) that may be impaired in people with cystic fibrosis. To be suitable for use in clinical and research settings, the tests must be valid, reliable, and feasible, with normative reference data available to assist with data interpretation.
In this issue, Sheppard et al2 evaluated the validity of 4 field tests (ie, 30-s sit-to-stand test, stair-climb power test, vertical jump height, and triple hop distance) as surrogate measures of quadriceps strength and power in subjects with cystic fibrosis. The rationale for this study centered around the fact that computerized dynamometry (eg, Cybex, CSMi, Stoughton, MA; or Biodex System 4 Pro, Biodex Medical Systems, Shirley, NY), which is the standard tool to evaluate peripheral muscle performance in humans, is costly and requires sufficient space and technical expertise. Based on their observed moderate-to-strong correlations between the performance on this battery of tests and quadriceps strength and the power assessed by computerized dynamometry, the authors recommended the use of these tests (and particularly the stair-climb power test) to assess quadriceps strength and power of people with cystic fibrosis. Although these findings underline the potential of such simple field tests to evaluate muscle performance in people with cystic fibrosis, these results should be interpreted with caution and several issues should be considered before these tests are considered fully appropriate for implementing into clinical practice.
These tests have primarily been used in older adults (eg, stair-climb power tests, 30-s sit-to-stand test) or healthy young adults (eg, vertical jump height and triple hop distance). Despite the increased survival age associated with cystic fibrosis, this is not particularly representative of the typical age of the cystic fibrosis population. Moreover, there is a lack of full validation studies, especially in people with cystic fibrosis. Some of these tests are dependent on technical aspects and may thus have a large learning effect, especially in sedentary individuals who are unaccustomed to this type of effort. Postural control, which is impaired in some people with cystic fibrosis,3 may also confound the performance in some tests (eg, triple hop distance) and test-retest reliability may be an issue. Moreover, as acknowledged by Sheppard et al2 their study, similar to previous work on this topic,4,5 is limited by the small sample size and possible selection bias. The absence of normative reference data for some of these tests within the age range of the cystic fibrosis population is also an issue.
It is therefore difficult to state whether the performance on a given test for a given patient is abnormal and, subsequently, decide on the most appropriate intervention to put in place. Accordingly, multi-centric validation of these tests (ie, learning effect, inter- and intra-rater reliability, construct validity, responsiveness, and minimally clinically important difference) in people with cystic fibrosis is needed in addition to the development of normative data for children and young adults. Although we agree that the correlations reported by Sheppard et al2 show interesting promise, for the reasons stated herein (ie, sample size, validity issues), it seems premature to use these tests as a valid surrogate of quadriceps strength in this population. Similar to the 1-min sit-to-stand test,4,5 these tests should be viewed as additional and complementary measures of limb muscle function to be considered for people with cystic fibrosis. The tests used by Sheppard et al2 have the advantage that they may better reflect activities of daily living compared with single-joint isometric or isotonic maneuvers and thus should display better ecological validity. However, confirmation of this is needed.
So, should we give up on strength measurements if computerized dynamometry is not available? Quite simply, no. Chairs with a fixed strain gauge offer an attractive (often underused) alternative for measuring limb muscle strength. Not only are commercially available or custom-built chairs with strain gauges (which allow isometric strength measurements) much cheaper than computerized dynamometry (usually ∼$5,000–$7,000), but strain gauge measures of quadriceps strength also show excellent validity (ie, vs computerized dynamometry) and are highly reliable (as much as are Biodex values6) in both healthy individuals7 and those individuals with chronic respiratory disorders.6 Moreover, normative data are available when using standardized procedures.8 Such chairs are also easily transportable and can be used to assess muscle function in other chronic respiratory conditions.9,10
Also, such isometric set-ups also enable assessments of limb muscle endurance and fatigability, which are often impaired in people with respiratory disease.10–12 However, fixed strain gauges have not yet been adapted to evaluate muscle power in cystic fibrosis. In the absence of computerized dynamometry, an interesting alternative could be the use of peak power achieved during short-duration cycling tests, such as the Wingate test. The Wingate test has often been used in cystic fibrosis as an indicator of anaerobic capacity13 and is well tolerated in this population. Such testing also provides a well-established measure of muscle power, which demonstrates strong agreement with other tests of muscle power determined when using computerized dynamometry (eg, repeated isokinetic contractions).14
In conclusion, we thank Sheppard et al2 for providing further support for the argument that the future of exercise testing in the cystic fibrosis clinic should, perhaps, include appropriate assessments of peripheral muscle function rather than focusing only on aerobic exercise function. Specifically, their findings support recent evidence,4,5 to substantiate the need to develop and implement simple functional tests that allow rapid evaluation of limb muscle function for people with cystic fibrosis. Moreover, their preliminary findings clearly call for further validation of such tests in the cystic fibrosis population and the establishment of appropriate normative reference values. In the meantime, we strongly encourage the use of chairs with strain gauge measurements, which have been shown to be clinically feasible, to evaluate strength, endurance, and fatigability of limb muscles in people with cystic fibrosis.9 Ultimately, the use of common methodology across cystic fibrosis centers to assess limb muscle function will promote the development of large prospective and retrospective multi-center studies, which are needed to (1) help us truly understand the prevalence, incidence, and development of limb muscle abnormalities in modern day cystic fibrosis; and (2) develop personalized therapeutic strategies targeting these issues.
Footnotes
- Correspondence: Mathieu Gruet, LAMHESS EA 6312, Université de Toulon, CS 60584 83041 Toulon Cedex 9, France. E-mail: gruet{at}univ-tln.fr.
The authors have disclosed no conflicts of interest.
- Copyright © 2019 by Daedalus Enterprises
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