TY - JOUR T1 - Low physical activity is a determinant for elevated blood pressure in high cardiovascular risk obstructive sleep apnea JF - Respiratory Care DO - 10.4187/respcare.02948 SP - respcare.02948 AU - Monique Mendelson AU - Renaud Tamisier AU - David Laplaud AU - Sonia Dias-Domingos AU - Jean-Philippe Baguet AU - Laurent Moreau AU - Christian Koltes AU - Léonidas Chavez AU - Gilles de Lamberterie AU - Frédéric Herengt AU - Patrick Levy AU - Patrice Flore AU - Jean-Louis Pépin Y1 - 2013/11/25 UR - http://rc.rcjournal.com/content/early/2013/11/26/respcare.02948.abstract N2 - Introduction: Obstructive Sleep Apnea (OSA) is associated with cardiovascular morbidity including hypertension. Beyond the severity of nocturnal hypoxia, others factors such as metabolic abnormalities but also sedentary behaviors and insufficient physical activity may contribute to elevated blood pressure (BP). To clarify the respective role of these factors as determinants of BP in OSA patients, we examined the relationship between BP and anthropometrics, severity of sleep apnea and objectively measured physical activity and sedentary behaviors. Methods: Ninety-five adults presenting with OSA (Apnea-Hypopnea Index (AHI) >10 events/hr) and high cardiovascular risk (63.3±8.8 years; BMI: 29.9±4.9 kg/m2; AHI: 41.3±17.5/hour; cardiovascular risk SCORE: 13.5±3.7) were included. Physical activity and sedentary behaviors were objectively assessed by actigraphy and self-measured home BP monitoring was measured. Logistic regression models adjusted for sex, age and BMI were built to identify the predictors of self-measured morning and evening BP. Results: Physical activity was significantly related to obesity but not with the severity of sleep apnea or sleepiness. Sedentary behaviors were associated with self-measured morning and evening systolic BP (r=0.32; p=0.0021; r=0.29; p=0.0043). Steps per day were inversely associated with evening BP (r=-0.27; p=0.0095). Univariate analysis identified steps per day and time spent in vigorous physical activity as determinants for evening self-measured BP. In multivariate analysis, only steps per day were identified as a significant determinant of evening BP. Conclusion: Physical activity is the major determinant for evening BP in adults with OSA presenting high cardiovascular risk. Our results emphasize the need for lifestyle counseling programs in combination with CPAP to encourage regular physical activity in OSA subjects and obtain better BP control. ER -