TY - JOUR T1 - Functional Respiratory Imaging as a tool to personalize respiratory treatment in subjects with unilateral diaphragmatic paralysis. JF - Respiratory Care DO - 10.4187/respcare.02756 SP - respcare.02756 AU - Cedric S Van Holsbeke AU - Glenn Leemans AU - Wim G Vos AU - Jan W De Backer AU - Samir C Vinchurkar AU - Michel Geldof AU - Pascal R Verdonck AU - Paul M Parizel AU - Paul E Van Schil AU - Wilfried A De Backer Y1 - 2013/12/10 UR - http://rc.rcjournal.com/content/early/2013/12/03/respcare.02756.abstract N2 - In two subjects with a unilateral diaphragmatic paralysis and complaints of dyspnea, a completely different treatment approach was chosen despite similar anatomical and physiological abnormalities. These decisions were supported by the results generated by Functional Respiratory Imaging (FRI). FRI was able to generate functional information with respect to lobar ventilation and local drug deposition. In one subject, it was found that some lobes were poorly ventilated and drug deposition simulation showed that some regions were undertreated. This subject underwent a diaphragm plication to restore the ventilation. In the other subject, it was found that all lobes were still ventilated. A conservative approach with regular follow-up was chosen to wait for spontaneous recovery of the diaphragmatic function. Both subjects improved subjectively and objectively. These cases demonstrate how novel medical imaging techniques such as FRI can be used to personalize respiratory treatment in subjects with unilateral diaphragmatic paralysis. ER -