TY - JOUR T1 - The interpretation of exhaled nitric oxide values in children with asthma depends on the degree of bronchoconstriction and the levels of asthma severity. JF - Respiratory Care DO - 10.4187/respcare.02889 SP - respcare.02889 AU - Grzelewski Tomasz AU - Majak Paweł AU - Jerzyńska Joanna AU - Stelmach Włodzimierz AU - Stelmach Rafał AU - Janas Anna AU - Grzelewska Aleksandra AU - Witkowski Konrad AU - Makandjou-Ola Eusebio AU - Stelmach Iwona Y1 - 2013/12/31 UR - http://rc.rcjournal.com/content/early/2013/12/31/respcare.02889.abstract N2 - Introduction: The clinical implications of FeNO measurements in childhood asthma are unclear. Aim: We aimed to evaluate the relationship between the level of exhaled nitric oxide and pre-bronchodilator FEV1 and the change in FEV1 after bronchodilator in children with asthma. Methods: It was a retrospective, cross-sectional study. We evaluated data from medical documentation of children with asthma with special attention to FeNO results, asthma severity, FEV1 (% predicted), and bronchial reversibility test (BRT). Results: Four hundred and five subjects (aged 6-18) completed the study. Median levels of FeNO increased linearly with subjects' age (p=0.025). We found a non-linear trend of pre-bronchodilator FEV1 across four quartiles of FeNO in episodic and mild asthma; we observed lower pre-bronchodilator FEV1 in children with higher FeNO, but only up to the FeNO value of 35.4 ppb; in children with FeNO value higher than 35.4 ppb, pre-bronchodilator FEV1 was increased. We found a linear increasing trend of change from baseline (after 400 mcg of salbutamol) in FEV1 across FeNO categories in children with moderate asthma. Conclusions: Our results suggest a need to measure FeNO before as well as after spirometry. Consequently, in children with asthma with bronchial obstruction we suggest assessing FeNO also after short-acting Beta2-agonists. ER -