PT  - JOURNAL ARTICLE
AU  - Se-Jin Kim
AU  - Sang-Don Han
AU  - Jung Yeon Lee
AU  - Gyu Rak Chon
TI  - A Case of Drug-Induced Interstitial Pneumonia Potentially Related to Quetiapine (Seroquel) Therapy for Behavioral and Psychological Symptoms
AID  - 10.4187/respcare.02977
DP  - 2014 Apr 29
TA  - Respiratory Care
PG  - respcare.02977
4099  - http://rc.rcjournal.com/content/early/2014/04/29/respcare.02977.short
4100  - http://rc.rcjournal.com/content/early/2014/04/29/respcare.02977.full
AB  - Quetiapine is regarded as an effective and safe treatment for delirium. An 82-year-old man presented with a 1-week history of violent behavior and dizziness accompanied by weakness on the left side of his body. He was diagnosed with acute cerebral cortical infarction and delirium associated with alcohol abuse. After quetiapine treatment, he complained of fever and coughed up sputum, whereas his aggressive behavior improved. His symptoms persisted despite empirical antibiotic treatment. All diagnostic tests for infectious causes were negative. High-resolution computed tomography revealed bilateral consolidations and ground-glass opacities with predominantly peribronchial and subpleural distributions. The primary differential diagnosis was drug-associated interstitial lung disease, and therefore, we discontinued quetiapine and began methylprednisolone treatment. His symptoms and radiologic findings significantly improved after receiving steroid therapy. We propose that clinicians need to be aware of the possibility that quetiapine is associated with lung injury.