RT Journal Article
SR Electronic
T1 High-frequency oscillatory ventilation versus synchronized intermittent mandatory ventilation plus pressure support in preterm infants with severe respiratory distress syndrome
JF Respiratory Care
FD American Association for Respiratory Care
SP respcare.02382
DO 10.4187/respcare.02382
A1 Huiqing Sun
A1 Rui Cheng
A1 Wengqing Kang
A1 Hong Xiong
A1 Chongchen Zhou
A1 Yinghui Zhang
A1 Xiaoyang Wang
A1 Changlian Zhu
YR 2013
UL http://rc.rcjournal.com/content/early/2013/06/13/respcare.02382.abstract
AB Background: Mechanical ventilation and surfactants are the standard treatment of preterm respiratory distress syndrome (RDS). The effects of the primary ventilation model on bronchopulmonary dysplasia (BPD) and long-term neurodevelopment outcomes are controversial. The purpose of this study was to compare the efficacy and safety of high-frequency oscillatory ventilation (HFOV) and synchronized intermittent mandatory ventilation plus pressure support ventilation (SIMV-PSV) in preterm infants with severe RDS. Methods: A total of 366 eligible preterm infants were randomly assigned to treatment with HFOV (n = 184) or SIMV-PSV (n = 182). Surfactant was applied if PaO2/FIO2 < 200 after 2 hours of ventilation. Primary outcomes were mortality or incidence of BPD. Secondary outcomes were duration of ventilation and hospitalization, surfactant requirements, pneumothorax, retinopathy of prematurity (ROP) ≥ stage 2, and neurodevelopment at 18 months of corrected age. Results: Survival and complete outcome data were available for 288 infants at 18 months of corrected age. Incidence of death or BPD was significantly higher in the SIMV-PSV group (p = 0.001). The duration of mechanical ventilation and hospitalization was shorter and the incidence of surfactant requirement and ROP was lower in the HFOV group (p < 0.05). Moderate or severe neurological disability was less frequent in the HFOV group than in the SIMV-PSV group at 18 months (p < 0.05). The combination of HFOV and surfactant dramatically reduced negative outcomes in preterm infants with severe RDS. Conclusion: Initial ventilation with HFOV in preterm infants with severe RDS reduces the incidence of death and BPD and improves long-term neurodevelopment outcomes.