RT Journal Article
SR Electronic
T1 IMPACT OF BRONCHODILATOR RESPONSIVENESS ON QUALITY OF LIFE AND EXERCISE CAPACITY IN PATIENTS WITH COPD
JF Respiratory Care
FD American Association for Respiratory Care
SP respcare.02399
DO 10.4187/respcare.02399
A1 Francisco Ortega
A1 Eduardo Márquez-Martín
A1 Borja Valencia
A1 Pilar Cejudo
A1 Ana Rodriguez
A1 Jose Luis López-Campos
A1 Emilia Barrot
YR 2013
UL http://rc.rcjournal.com/content/early/2013/08/16/respcare.02399.abstract
AB Background: Bronchial variability in COPD patients may be a phenotypic feature associated with clinical characteristics and differential treatment response. Objectives: We analysed whether symptoms, quality of life and exercise capacity varied in COPD patients as a function of bronchodilator test results. Further, we compared response to an exercise programme in the groups. Methods: A positive bronchodilator test result was defined as FVC and/or FEV1>12% plus >200 ml improvement after 400 μg salbutamol. We studied 198 COPD patients, 94 with positive reversibility and 104 with negative reversibility. Training sessions were carried out on three non-consecutive days each week for 12 weeks, and consisted of a combination of resistance and strength training. Subjects were evaluated on two consecutive days at baseline, and at the end of the 12-week training programme. Results: Those with positive reversibility had shorter time—to-exhaustion on the endurance test (19.1±12.6 min versus 24.5±14.5 min in negative reversibility patients; p<0.031), shorter distances in the shuttle walking test (380.6 ± 158.2 m versus 438.5±149.1 m in negative reversibility patients; p<0.029) and lower scores on the Chronic Respiratory Disease Questionnaire (18.7±4.6 versus 19.8±4.3 in negative reversibility patients; p<0.015), while we found no significant differences in peak exercise, peripheral muscle strength or dyspnoea. Further, differences between groups in improvements after exercise training were not significant. Conclusions: Compared to COPD patients with negative reversibility, those with positive reversibility walk for shorter distances, and have shorter endurance times and a worse quality of life, but improvements after exercise training are similar.