RT Journal Article
SR Electronic
T1 Necrotizing Sarcoid Granulomatosis With an Uncommon Manifestation: Clinicopathological Features and Review of Literature
JF Respiratory Care
FD American Association for Respiratory Care
SP respcare.02842
DO 10.4187/respcare.02842
A1 Chiara Giraudo
A1 Nazarena Nannini
A1 Elisabetta Balestro
A1 Alessia Meneghin
A1 Francesca Lunardi
A1 Roberta Polverosi
A1 Fiorella Calabrese
YR 2014
UL http://rc.rcjournal.com/content/early/2014/08/05/respcare.02842.abstract
AB We report a rare case of an incidental diagnosis of necrotizing sarcoid granulomatosis (NSG) in a 60-y-old non-smoking male. The patient was admitted to the hospital for sudden back pain. Chest x-ray revealed areas of parenchymal consolidation and high-resolution computed tomography demonstrated a pulmonary nodular pattern with no lymph node enlargement. All laboratory and pulmonary function tests were normal. Bronchoscopy with bronchoalveolar lavage showed no sign of infection or specific inflammation. The diagnosis of NSG was made by histopathological examination of a surgical lung biopsy and by excluding other causes of granulomatous disease. In paucisymptomatic/asymptomatic patients, as in our case, therapy is not necessary, with a good prognosis and complete recovery. NSG is a rare systemic disease similar to sarcoidosis and Wegener’s granulomatosis with a benign clinical course and should always be considered for patients with nodular pulmonary lesions even with subclinical or uncommon features.