RT Journal Article SR Electronic T1 Functional Respiratory Imaging as a Tool to Personalize Respiratory Treatment in Patients With Unilateral Diaphragmatic Paralysis JF Respiratory Care FD American Association for Respiratory Care SP respcare.02756 DO 10.4187/respcare.02756 A1 Cedric S Van Holsbeke A1 Glenn Leemans A1 Wim G Vos A1 Jan W De Backer A1 Samir C Vinchurkar A1 Michel Geldof A1 Pascal R Verdonck A1 Paul M Parizel A1 Paul E Van Schil A1 Wilfried A De Backer YR 2014 UL http://rc.rcjournal.com/content/early/2014/08/12/respcare.02756.abstract AB A completely different treatment approach was chosen for 2 patients with unilateral diaphragmatic paralysis and complaints of dyspnea despite similar anatomic and physiologic abnormalities. These decisions were supported by results obtained by functional respiratory imaging (FRI). FRI generated functional information on lobar ventilation and local drug deposition. In the first patient, some lobes were poorly ventilated, and drug deposition simulation showed that some regions were undertreated. This patient underwent diaphragmatic plication to restore ventilation. In the second patient, all lobes were still ventilated. A conservative approach with regular follow-ups was chosen to wait for spontaneous recovery of the diaphragmatic function. Both patients improved subjectively and objectively. These cases demonstrate how novel medical imaging techniques such as FRI can be used to personalize respiratory treatment in patients with unilateral diaphragmatic paralysis.