TY - JOUR T1 - Use and Outcomes of Noninvasive Ventilation for Acute Respiratory Failure in Different Age Groups JF - Respiratory Care DO - 10.4187/respcare.03966 SP - respcare.03966 AU - Aylin Ozsancak Ugurlu AU - Samy S Sidhom AU - Ali Khodabandeh AU - Michael Ieong AU - Chester Mohr AU - Denis Y Lin AU - Irwin Buchwald AU - Imad Bahhady AU - John Wengryn AU - Vinay Maheshwari AU - Nicholas S Hill Y1 - 2015/09/15 UR - http://rc.rcjournal.com/content/early/2015/09/15/respcare.03966.abstract N2 - BACKGROUND: The prevalence of chronic disease and do-not-intubate status increases with age. Thus, we aimed to determine characteristics and outcomes associated with noninvasive ventilation (NIV) use for acute respiratory failure (ARF) in different age groups.METHODS: A database comprising prospective data collected on site on all adult patients with ARF requiring ventilatory support from 8 acute care hospitals in Massachusetts was used.RESULTS: From a total of 1,225 ventilator starts, overall NIV utilization, success, and in-hospital mortality rates were 22, 54, and 18% in younger (18–44 y); 34, 65, and 13% in middle-aged (45–64 y); 49, 68, and 17% in elderly (65–79 y); and 47, 76, and 24% in aged (≥80 y) groups, respectively (P < .001, P = .08, and P = .11, respectively). NIV use for cardiogenic pulmonary edema and subjects with a do-not-intubate order increased significantly with advancing age (25, 57, 57, and 74% and 7, 12, 18, and 31%, respectively, in the 4 age groups [P < .001 and P = .046, respectively]). For subjects receiving NIV with a do-not-intubate order, success and in-hospital mortality rates were similar in different age groups (P = .27 and P = .98, respectively).CONCLUSIONS: NIV use and a do-not-intubate status are more frequent in subjects with ARF ≥65 y than in those <65 y, especially for subjects with cardiogenic pulmonary edema. However, NIV success and mortality rates were similar between age groups. ER -