@article {Moererrespcare.04141, author = {Onnen Moerer and Lars-Olav Harnisch and Peter Herrmann and Carsten Zippel and Michael Quintel}, title = {Patient-Ventilator Interaction During Noninvasive Ventilation in Simulated COPD}, elocation-id = {respcare.04141}, year = {2015}, doi = {10.4187/respcare.04141}, publisher = {Respiratory Care}, abstract = {BACKGROUND: During noninvasive ventilation (NIV) of COPD patients, delayed off-cycling of pressure support can cause patient ventilator mismatch and NIV failure. This systematic experimental study analyzes the effects of varying cycling criteria on patient-ventilator interaction.METHODS: A lung simulator with COPD settings was connected to an ICU ventilator via helmet or face mask. Cycling was varied between 10 and 70\% of peak inspiratory flow at different breathing frequencies (15 and 30 breaths/min) and pressure support levels (5 and 15 cm H2O) using the ventilator{\textquoteright}s invasive and NIV mode with and without an applied leakage.RESULTS: Low cycling criteria led to severe expiratory cycle latency. Augmenting off-cycling reduced expiratory cycle latency (P \< .001), decreased intrinsic PEEP, and avoided non-supported breaths. Setting cycling to 50\% of peak inspiratory flow achieved best synchronization. Overall, using the helmet interface increased expiratory cycle latency in almost all settings (P \< .001). Augmenting cycling from 10 to 40\% progressively decreased expiratory pressure load (P \< .001). NIV mode decreased expiratory cycle latency compared with the invasive mode (P \< .001).CONCLUSION: Augmenting the cycling criterion above the default setting (20{\textendash}30\% peak inspiratory flow) improved patient ventilator synchrony in a simulated COPD model. This suggests that an individual approach to cycling should be considered, since interface, level of pressure support, breathing frequency, and leakage influence patient-ventilator interaction and thus need to be considered.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/early/2015/11/10/respcare.04141}, eprint = {https://rc.rcjournal.com/content/early/2015/11/10/respcare.04141.full.pdf}, journal = {Respiratory Care} }