RT Journal Article SR Electronic T1 The History and Physics of Heliox JF Respiratory Care FD American Association for Respiratory Care SP 608 OP 612 VO 51 IS 6 A1 Dean R Hess A1 James B Fink A1 Shekhar T Venkataraman A1 IN K Kim A1 Timothy R Myers A1 Benoit D Tano YR 2006 UL http://rc.rcjournal.com/content/51/6/608.abstract AB Since the discovery of helium in 1868, it has found numerous applications in industry and medicine. Its low density makes helium potentially valuable in respiratory care applications, to reduce work of breathing, improve distribution of ventilation, reduce minute volume requirement, and improve aerosol delivery. This review includes a brief history of the use of heliox (a mixture of helium and oxygen) and addresses issues related to the physics of gas flow when heliox is used. Specifically covered are the Hagen-Poiseuille equation, laminar versus turbulent flow, the Reynolds number, orifice flow, Bernoulli's principle, Graham's law, wave speed, and thermal conductivity.