RT Journal Article SR Electronic T1 Immediate Changes in Blood-Gas Tensions During Chest Physiotherapy With Positive Expiratory Pressure and Oscillating Positive Expiratory Pressure in Patients With Cystic Fibrosis JF Respiratory Care FD American Association for Respiratory Care SP 1154 OP 1161 VO 51 IS 10 A1 Anna-Lena B Lagerkvist A1 Gunilla M Sten A1 Staffan B Redfors A1 Anders G Lindblad A1 Ola Hjalmarson YR 2006 UL http://rc.rcjournal.com/content/51/10/1154.abstract AB OBJECTIVE: To assess and compare immediate effects of chest physiotherapy with positive expiratory pressure (PEP) versus oscillating PEP on transcutaneously measured blood-gas tensions in patients with cystic fibrosis. METHODS: Fifteen patients (mean age 12.5 y, range 6.9–21.5 y) participated. The treatments were randomized and performed on 2 separate occasions, 8 weeks apart. Spirometry was conducted before and after each treatment. We transcutaneously measured oxygen tension (PtO2) and carbon dioxide tension (PtCO2) 20 min before, during, and 10 min after each treatment. RESULTS: There were no changes in spirometry values. During PEP, different trends in blood-gas tension were seen, and there were no consistent changes. During oscillating PEP, PtO2 increased and PtCO2 decreased. During oscillating PEP, PtCO2 was lower and the intra-individual change in PtCO2 was more pronounced than during PEP. The results obtained immediately after oscillating PEP showed a higher PtO2 and a lower PtCO2 than with PEP. CONCLUSION: PEP and oscillating PEP can both cause transitory effects on blood gases in patients with cystic fibrosis. However, oscillating PEP alters blood-gas tensions more than does PEP, and hyperventilation during oscillating PEP may reduce treatment time.