RT Journal Article
SR Electronic
T1 Pulmonary Vasodilators
JF Respiratory Care
FD American Association for Respiratory Care
SP 885
OP 899
VO 52
IS 7
A1 Siobal, Mark S
YR 2007
UL http://rc.rcjournal.com/content/52/7/885.abstract
AB Pulmonary vasodilators are an important treatment for pulmonary arterial hypertension. They reduce pulmonary artery pressure; improve hemodynamic function; alter ventilation/perfusion matching in the lungs; and improve functional quality of life, exercise tolerance, and survival in patients with severe pulmonary arterial hypertension. This paper reviews the currently available pulmonary vasodilators and those under development, many of which can be administered via inhalation. I will also give an overview of the clinical pharmacology of, the indications for, and the evidence supporting pulmonary vasodilators, their delivery via inhalation, and potential toxic and adverse effects.