PT  - JOURNAL ARTICLE
AU  - Seung Jun Lee
AU  - Hyo-Jung Kim
AU  - Ju-Young Kim
AU  - Sunmi Ju
AU  - Sujin Lim
AU  - Jung Wan Yoo
AU  - Sung-Jin Nam
AU  - Gi Dong Lee
AU  - Hyun Seop Cho
AU  - Rock Bum Kim
AU  - Yu Ji Cho
AU  - Yi Yeong Jeong
AU  - Ho Cheol Kim
AU  - Jong Deog Lee
TI  - Serum Albumin and Disease Severity of Non-Cystic Fibrosis Bronchiectasis
AID  - 10.4187/respcare.05276
DP  - 2017 Aug 01
TA  - Respiratory Care
PG  - 1075--1084
VI  - 62
IP  - 8
4099  - http://rc.rcjournal.com/content/62/8/1075.short
4100  - http://rc.rcjournal.com/content/62/8/1075.full
AB  - BACKGROUND: A clinical classification system has been developed to define the severity and predict the prognosis of subjects with non-cystic fibrosis (CF) bronchiectasis. We aimed to identify laboratory parameters that are correlated with the bronchiectasis severity index (BSI) and FACED score.METHODS: The medical records of 107 subjects with non-CF bronchiectasis for whom BSI and FACED scores could be calculated were retrospectively reviewed. The correlations between the laboratory parameters and BSI or FACED score were assessed, and multiple-linear regression analysis was performed to identify variables independently associated with BSI and FACED score. An additional subgroup analysis was performed according to sex.RESULTS: Among all of the enrolled subjects, 49 (45.8%) were male and 58 (54.2%) were female. The mean BSI and FACED scores were 9.43 ± 3.81 and 1.92 ± 1.59, respectively. The serum albumin level (r = −0.49), bilirubin level (r = −0.31), C-reactive protein level (r = 0.22), hemoglobin level (r = −0.2), and platelet/lymphocyte ratio (r = 0.31) were significantly correlated with BSI. Meanwhile, serum albumin (r = −0.37) and bilirubin level (r = −0.25) showed a significant correlation with the FACED score. Multiple-linear regression analysis showed that the serum bilirubin level was independently associated with BSI, and the serum albumin level was independently associated with both scoring systems. Subgroup analysis revealed that the level of uric acid was also a significant variable independently associated with the BSI in male bronchiectasis subjects.CONCLUSIONS: Several laboratory variables were identified as possible prognostic factors for non-CF bronchiectasis. Among them, the serum albumin level exhibited the strongest correlation and was identified as an independent variable associated with the BSI and FACED scores.