RT Journal Article
SR Electronic
T1 Aerosol Delivery Through Adult High Flow Nasal Cannula With Heliox and Oxygen
JF Respiratory Care
FD American Association for Respiratory Care
SP 1186
OP 1192
DO 10.4187/respcare.05127
VO 62
IS 9
A1 Dailey, Patricia A
A1 Harwood, Robert
A1 Walsh, Kyle
A1 Fink, James B
A1 Thayer, Tina
A1 Gagnon, Greg
A1 Ari, Arzu
YR 2017
UL http://rc.rcjournal.com/content/62/9/1186.abstract
AB BACKGROUND: Heliox (helium-oxygen mixture) has been shown to reduce turbulence and improve aerosol delivery in a range of clinical settings. We questioned whether heliox as compared with oxygen via high-flow nasal cannula (HFNC) would affect aerosol delivery. We hypothesized that heliox would have a significant effect on aerosol delivery as compared with oxygen with both quiet and distressed breathing patterns.METHODS: A vibrating mesh nebulizer was placed at the inlet of a humidifier via HFNC with small adult cannula distal to the heated-wire circuit with prongs placed into simulated nares with a T-shaped trap and absolute filter connected to a breath simulator set to adult quiet and distressed breathing parameters. Albuterol sulfate (0.083% 2.5 mg/3 mL) was aerosolized with heliox (80:20) and oxygen (100%) at 10, 30, and 50 L/min. Drug eluted from the filter was assayed with UV spectrophotometry (276 nm). Descriptive statistics, Kruskal-Wallis test, and Mann-Whitney U test were used for data analysis. P < .05 was considered statistically significant.RESULTS: Increasing flows with heliox and oxygen significantly decreased percentage inhaled dose (inhaled dose) of aerosol with a quiet breathing pattern (P = .02 and P = .030, respectively). In contrast, with a distressed breathing pattern, inhaled dose at 10 L/min was lower than at 30 and 50 L/min (P = .009 and P = .01, respectively) with both oxygen and heliox (P = .009 and P = .009, respectively). Despite a trend to higher aerosol deposition with heliox versus oxygen, the differences were not significant.CONCLUSIONS: With a distressed breathing pattern, aerosol delivery was greater at 30 and 50 L/min than with a quiet breathing pattern. Trends toward higher inhaled dose with heliox during HFNC were not significant.