RT Journal Article
SR Electronic
T1 Ventilator-Induced Diaphragmatic Dysfunction: Diagnosis and Role of Pharmacological Agents
JF Respiratory Care
FD American Association for Respiratory Care
SP 1485
OP 1491
DO 10.4187/respcare.05622
VO 62
IS 11
A1 Won-Young Kim
A1 Chae-Man Lim
YR 2017
UL http://rc.rcjournal.com/content/62/11/1485.abstract
AB The use of controlled mechanical ventilation results in a major reduction of diaphragmatic contractile force together with atrophy of diaphragm muscle fibers, which is a condition known as ventilator-induced diaphragmatic dysfunction. Ventilator-induced diaphragmatic dysfunction is one of the major contributors to weaning difficulties and even increased mortality. This review summarizes the current data on the pathogenesis and diagnosis of ventilator-induced diaphragmatic dysfunction, and it outlines the use of ultrasonography for diaphragm evaluation. In addition, current pharmacologic agents used to mitigate ventilator-induced diaphragmatic dysfunction are described, with a particular emphasis on the therapeutic potential of theophylline in patients with ventilator-induced diaphragmatic dysfunction-associated weaning difficulties.