RT Journal Article SR Electronic T1 Reference Values for the 6-min Walk Distance (6MWT) in Healthy Children Aged 7 to 12 Years in Brazil: Main Results of the TC6minBRASIL Multi-Center Study JF Respiratory Care FD American Association for Respiratory Care SP respcare.05686 DO 10.4187/respcare.05686 A1 Lucas de Assis Pereira Cacau A1 Vitor Oliveira Carvalho A1 Alessandro dos Santos Pin A1 Carlos Raphael Araujo Daniel A1 Daisy Satomi Ykeda A1 Eliane Maria de Carvalho A1 Juliana Valente Francica A1 Luíza Martins Faria A1 Mansueto Gomes-Neto A1 Marcelo Fernandes A1 Marcelo Velloso A1 Marlus Karsten A1 Patrícia de Sá Barros A1 Valter Joviniano de Santana-Filho A1 , YR 2017 UL http://rc.rcjournal.com/content/early/2017/11/21/respcare.05686.abstract AB INTRODUCTION: Brazil is a country with great climatic, socioeconomic, and cultural differences that does not yet have a reference value for the 6-min walk test (6MWT) in healthy children. To avoid misinterpretation, the use of equations to predict the maximum walking distance should be established in each country.OBJECTIVES: We sought to establish reference values and to develop an equation to predict the 6-min walk distance (6MWT) for healthy children in Brazil.METHODS: This is a cross-sectional multi-center study that included 1,496 healthy children, aged 7 to 12 y, assessed across 11 research sites in all regions of Brazil, and recruited from public and private schools in their respective regions. Each child was assessed for weight and height. Walking distance was our main outcome. An open-source software environment for statistical computing was used for statistical analysis.RESULTS: We observed a higher average distance walked by boys (531.1 m) than by girls (506.2 m), with a difference of 24.9 m (P < .001). We established 6MWT reference values for boys with the following equation: Distance = (16.86 × age) + (1.89 × Δ heart rate) − (0.80 × weight) + (336.91 × R1) + (360.91 × R2). For girls the equation is as follows: Distance = (13.54 × age) + (1.62 × Δ heart rate) − (1.28 × weight) + (352.33 × R1) + (394.81 × R2).CONCLUSION: Reference values were established for the 6MWT in healthy children aged 7–12 y in Brazil.