TY - JOUR T1 - The Role of Multidetector Computed Tomography and the Forced Oscillation Technique in Assessing Lung Damage in Adults With Cystic Fibrosis JF - Respiratory Care DO - 10.4187/respcare.05815 SP - respcare.05815 AU - Letícia S Lacerda AU - Agnaldo J Lopes AU - Alysson R S Carvalho AU - Alan R M Guimarães AU - Mônica C Firmida AU - Marcos C S Castro AU - Roberto Mogami AU - Pedro L Melo Y1 - 2017/12/05 UR - http://rc.rcjournal.com/content/early/2017/12/05/respcare.05815.abstract N2 - BACKGROUND: With increased survival rates and the consequent emergence of an adult population with cystic fibrosis (CF), developing novel tools for periodic evaluations of these patients has become a new challenge. Thus, we sought to determine the contribution of lung-volume quantification using multidetector computed tomography (CT) in adults with CF and to investigate the association between structural changes and functional abnormalities.METHODS: This was a cross-sectional study in which 21 adults with CF and 22 control subjects underwent lung-volume quantification using multidetector CT. Voxel densities were divided into 4 bands: −1,000 to −900 Hounsfield units (HU) (hyperaerated region), −900 to −500 HU (normally aerated region), −500 to −100 HU (poorly aerated region), and −100 to 100 HU (non-aerated region). In addition, all participants performed pulmonary function tests including spirometry, body plethysmography, diffusion capacity for carbon monoxide, and the forced oscillation technique.RESULTS: Adults with CF had more non-aerated regions and poorly aerated regions with lung-volume quantification using multidetector CT than controls. Despite these abnormalities, total lung volume measured by lung-volume quantification using multidetector CT did not differ between subjects and controls. Total lung capacity (TLC) measured by body plethysmography correlated with both total lung volume (rs = 0.71, P < .001) and total air volume (rs = 0.71, P < .001) as measured with lung-volume quantification using multidetector CT. While the hyperaerated regions correlated with the functional markers of gas retention in the lungs (increased residual volume (RV) and RV/TLC ratio), the poorly aerated regions correlated with the resistive parameters measured by the forced oscillation technique (increased intercept resistance and mean resistance). We also observed a correlation between normally aerated regions and highest pulmonary diffusion values (rs = 0.68, P < .001).CONCLUSIONS: In adults with CF, lung-volume quantification using multidetector CT can estimate the lung volumes of compartments with different densities and determine the aerated and non-aerated contents of the lungs; furthermore, lung-volume quantification using multidetector CT is clearly related to pulmonary function parameters. ER -