TY - JOUR T1 - Prolonged Mechanical Ventilation as a Predictor of Mortality After Cardiac Surgery JF - Respiratory Care SP - 550 LP - 557 DO - 10.4187/respcare.04915 VL - 63 IS - 5 AU - Maria Dolores Fernandez-Zamora AU - Antonio Gordillo-Brenes AU - Esther Banderas-Bravo AU - José Andrés Arboleda-Sánchez AU - Rafael Hinojosa-Pérez AU - Eduardo Aguilar-Alonso AU - Ángel Herruzo-Aviles AU - Emilio Curiel-Balsera AU - Ángel Sánchez-Rodríguez AU - Ricardo Rivera-Fernández AU - the ARIAM Andalucía Group Y1 - 2018/05/01 UR - http://rc.rcjournal.com/content/63/5/550.abstract N2 - BACKGROUND: Mortality among the small percentage of cardiac surgery patients receiving prolonged mechanical ventilation is high, but this issue appears to be inadequately addressed in guidelines.METHODS: This study is a retrospective analysis of prospective, multi-center, and observational study in Spain including all adults undergoing cardiac surgery in 3 Andalusian hospitals between June 2008 and December 2012.RESULTS: The study included 3,588 adults with mean ± SD age of 63.5 ± 12.8 y and with median (interquartile range) EuroSCORE of 5 (3–7) points. Prolonged mechanical ventilation (> 24 h) was required by 415 subjects (11.6%), with ICU mortality of 44.3% (184 subjects), and was not required by 3,173 subjects (88.4%), with ICU mortality of 3.1% (99 subjects, P < .001). Prolonged mechanical ventilation was associated with more complications and was required by 4.5% of subjects with a EuroSCORE <5, 11.2% with a score of 5–7, 27.2% with a score of 8–10, and 32.2% with a score > 10. In the multivariable analysis, ICU mortality was associated with illness severity, duration of bypass surgery, surgery type, and prolonged mechanical ventilation (odds ratio 15.19, 95% CI 11.56–22.09). The main cause of death was multiple organ failure and sepsis in subjects who required prolonged mechanical ventilation (50.3%) and cardiogenic shock in those who did not (59.2%).CONCLUSION: Prolonged postoperative mechanical ventilation was required by 10–20% of cardiac surgery subjects, who constitute a specific group that represents most of the postoperative mortality, which is associated with multiple organ failure and sepsis. ER -