PT  - JOURNAL ARTICLE
AU  - Mouri, Hideyuki
AU  - Jo, Taisuke
AU  - Michihata, Nobuaki
AU  - Matsui, Hiroki
AU  - Fushimi, Kiyohide
AU  - Yasunaga, Hideo
TI  - Continuous Neuromuscular Blockade and Mortality in Subjects With Exacerbation of Idiopathic Interstitial Pneumonias
AID  - 10.4187/respcare.06289
DP  - 2018 Aug 28
TA  - Respiratory Care
PG  - respcare.06289
4099  - http://rc.rcjournal.com/content/early/2018/08/28/respcare.06289.short
4100  - http://rc.rcjournal.com/content/early/2018/08/28/respcare.06289.full
AB  - BACKGROUND: Exacerbation of idiopathic interstitial pneumonias (IIPs) requiring mechanical ventilation is associated with high mortality. However, evidence for the optimal management strategy in patients on mechanical ventilation for exacerbation of IIPs is scarce. This study aimed to evaluate the association between continuous rocuronium infusion and in-hospital mortality in patients with exacerbation of IIPs requiring mechanical ventilation.METHODS: The effect of continuous rocuronium infusion was retrospectively analyzed using data in the Japanese Diagnosis Procedure Combination in-patient database from July 2010 to March 2016. We compared 28-d mortality between the continuous rocuronium infusion group (intravenous doses of ≥ 150 mg/d) and the control group using 1:4 propensity score matching.RESULTS: We enrolled 4,925 subjects. Propensity score matching yielded 66 subjects in the rocuronium group and 264 subjects in the control group. There was no significant difference in 28-d mortality (rocuronium vs control, 52% vs 44%, P = .31) or in-hospital mortality (68% vs 61%, P = .28) between the 2 groups.CONCLUSIONS: Continuous rocuronium infusion was not significantly associated with decreased mortality in patients with exacerbation of IIPs requiring mechanical ventilation.