PT - JOURNAL ARTICLE AU - Rosa Mar Gómez Punter AU - Rosa M Girón Moreno AU - Emma Vázquez Espinosa AU - Joan B Soriano AU - M Teresa Pastor AU - Enrique Zamora AU - Claudia Valenzuela AU - Tamara Alonso AU - Elena García Castillo AU - Julio Ancochea TI - Desaturations During 6-Minute Walk Test and Predicting Nocturnal Desaturations in Adult Subjects With Cystic Fibrosis AID - 10.4187/respcare.06171 DP - 2018 Nov 20 TA - Respiratory Care PG - respcare.06171 4099 - http://rc.rcjournal.com/content/early/2018/11/20/respcare.06171.short 4100 - http://rc.rcjournal.com/content/early/2018/11/20/respcare.06171.full AB - BACKGROUND: Nocturnal desaturation in cystic fibrosis (CF) may have prognostic implications because a significant and maintained nocturnal desaturation can contribute to the development and progression of pulmonary hypertension with cor pulmonale. Its relation with the desaturation in exercise has not been sufficiently studied. We aimed to determine whether desaturation during 6MWT can be an indicator of nocturnal desaturation in adult subjects with CF.METHODS: 57 subjects were included: 50.9% male, 27.5 ± 7.7 y old, mean FEV1 = 2.37 ± 0.74 L, and %FEV1 67 ± 18.1%. Desaturation during 6MWT was defined as oxygen saturation (SpO2) ≤ 90% or a decline of > 4 points in SpO2 from baseline, and nocturnal desaturation as a desaturation index > 4 or > 5% of sleep time with SpO2 ≤ 90%.RESULTS: Desaturation observed during 6MWT in adult subjects with CF did not correlate with nocturnal desaturation (P = .27). Subjects with %FEV1 ≤ 55% and diffusion capacity of carbon monoxide (DLCO) ≤ 50 mmol/min/mm Hg were at higher risk of 6MWT desaturation. Nocturnal desaturation was more frequent in males, with PaO2 ≤ 71 mm Hg in blood gas analysis.CONCLUSIONS: Desaturation observed in 6MWT cannot predict desaturation at night in adults with CF. Other parameters were identified as predictors of desaturation.