RT Journal Article
SR Electronic
T1 Desaturations During 6-Minute Walk Test and Predicting Nocturnal Desaturations in Adult Subjects With Cystic Fibrosis
JF Respiratory Care
FD American Association for Respiratory Care
SP 48
OP 54
DO 10.4187/respcare.06171
VO 64
IS 1
A1 Gómez Punter, Rosa Mar
A1 Girón Moreno, Rosa M
A1 Vázquez Espinosa, Emma
A1 Soriano, Joan B
A1 Pastor, M Teresa
A1 Zamora, Enrique
A1 Valenzuela, Claudia
A1 Alonso, Tamara
A1 García Castillo, Elena
A1 Ancochea, Julio
YR 2019
UL http://rc.rcjournal.com/content/64/1/48.abstract
AB BACKGROUND: Nocturnal desaturation in cystic fibrosis (CF) may have prognostic implications because a significant and maintained nocturnal desaturation can contribute to the development and progression of pulmonary hypertension with cor pulmonale. Its relation with the desaturation in exercise has not been sufficiently studied. We aimed to determine whether desaturation during 6MWT can be an indicator of nocturnal desaturation in adult subjects with CF.METHODS: 57 subjects were included: 50.9% male, 27.5 ± 7.7 y old, mean FEV1 = 2.37 ± 0.74 L, and %FEV1 67 ± 18.1%. Desaturation during 6MWT was defined as oxygen saturation (SpO2) ≤ 90% or a decline of > 4 points in SpO2 from baseline, and nocturnal desaturation as a desaturation index > 4 or > 5% of sleep time with SpO2 ≤ 90%.RESULTS: Desaturation observed during 6MWT in adult subjects with CF did not correlate with nocturnal desaturation (P = .27). Subjects with %FEV1 ≤ 55% and diffusion capacity of carbon monoxide (DLCO) ≤ 50 mmol/min/mm Hg were at higher risk of 6MWT desaturation. Nocturnal desaturation was more frequent in males, with PaO2 ≤ 71 mm Hg in blood gas analysis.CONCLUSIONS: Desaturation observed in 6MWT cannot predict desaturation at night in adults with CF. Other parameters were identified as predictors of desaturation.