RT Journal Article
SR Electronic
T1 A Study of the Physiologic Responses to a Lung Recruitment Maneuver in Acute Lung Injury and Acute Respiratory Distress Syndrome
JF Respiratory Care
FD American Association for Respiratory Care
SP 1441
OP 1449
VO 53
IS 11
A1 Maureen O Meade
A1 Deborah J Cook
A1 Lauren E Griffith
A1 Lori E Hand
A1 Stephen E Lapinsky
A1 Thomas E Stewart
A1 Kieran J Killian
A1 Arthur S Slutsky
A1 Gordon H Guyatt
YR 2008
UL http://rc.rcjournal.com/content/53/11/1441.abstract
AB OBJECTIVE: To determine the magnitude, duration, and consistency of the effects of lung recruitment maneuvers (RMs) on oxygenation, lung mechanics, and comfort in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). METHODS: We conducted a prospective physiologic study at 3 tertiary-care hospitals. We enrolled 28 consecutive eligible patients with ARDS or ALI and a ratio of PaO2 to fraction of inspired oxygen (PaO2/FIO2) ≤ 250 mm Hg while receiving FIO2 ≥ 0.50. We performed RMs twice daily for 3 days. The first RM was at 35 cm H2O for 20 s. If initial response was equivocal, the clinician immediately administered another RM at a higher pressure (40 cm H2O, then 45 cm H2O) or for longer period (30 s, then 40 s), in a randomized order. Each patient had up to 6 sets of up to 3 RMs. RESULTS: Twenty-seven patients met the criteria for ARDS at baseline; 1 had ALI. There was no net effect on oxygenation or pulmonary mechanics following the first or subsequent RMs. The largest rise in PaO2 was from 61 mm Hg to 71 mm Hg, and the largest decrease was 6 mm Hg following the first RM. Augmenting the inflation pressure or duration had no significant effect. These findings precluded analyses about predictors of response or consistency of response. Over the entire study of 122 RMs, 5 patients developed ventilator asynchrony, 3 appeared uncomfortable, 2 experienced transient hypotension, and 4 developed barotrauma that required intervention. CONCLUSIONS: These results do not support the addition of scheduled RMs to usual treatment for ALI or ARDS.