PT  - JOURNAL ARTICLE
AU  - Selman, Jessyca P
AU  - Lanza, Fernanda C
AU  - Wandalsen, Gustavo F
AU  - Solé, Dirceu
AU  - O'Donnell, Denis E
AU  - Neder, J Alberto
AU  - Dal Corso, Simone
TI  - Ventilatory Demand During Stepping and Running: Implications for Exercise-Induced Bronchoconstriction in Children
AID  - 10.4187/respcare.06363
DP  - 2019 Feb 05
TA  - Respiratory Care
PG  - respcare.06363
4099  - http://rc.rcjournal.com/content/early/2019/02/05/respcare.06363.short
4100  - http://rc.rcjournal.com/content/early/2019/02/05/respcare.06363.full
AB  - BACKGROUND: Single-step tests have been proposed as simple and inexpensive challenges to diagnose exercise-induced bronchoconstriction (EIB) in the pediatric population. Work performed and the resulting ventilation, however, might be substantially lower in stepping than running. This might decrease the diagnostic yield of step-based challenges.METHODS: In a cross-sectional study, 53 children with asthma with exercise-related symptoms (34 boys, age 6–18 y) underwent an incremental stepping test, a 6-min constant stepping test, and a treadmill running test on different days.RESULTS: Constant and incremental stepping tests presented with lower metabolic demands (V̇O2 1.42 ± 0.48 and 1.34 ± 0.55 L/min, respectively), ventilatory demands (V̇O2 45 ± 14 and 43 ± 16 L/min, respectively), and cardiovascular demands (160 ± 20 and 161 ± 19 beats/min, respectively) than the treadmill running test (1.65 ± 0.60 L/min, 54 ± 17 L/min, and 172 ± 7 beats/min, respectively) (P < .05). Between-test agreement in diagnosing EIB was poor (kappa 0.217–0.361). Although EIB prevalence was higher after the treadmill running test (60%) compared to constant (53%) and incremental (47%) stepping tests, 7 subjects developed EIB only in stepping. Clinical and resting functional characteristics did not differ in discordant subjects (ie, EIB negative in a given test but positive in another) versus concordant subjects (ie, EIB negative or positive in both tests). EIB was not related to individual test ability in eliciting high to very-high ventilation (≥ 40% or ≥ 60% maximum voluntary ventilation, respectively). Moreover, a negative stepping test but a positive treadmill test (and vice versa) was not associated with greater ventilatory demands.CONCLUSIONS: Lower prevalence of EIB in stepping compared to treadmill running is not related to less ventilation demand in the former modality. Although stepping might be useful as a screening EIB test due its portability and low cost, a negative test should be confirmed with a running-based test in symptomatic children.