PT  - JOURNAL ARTICLE
AU  - Insel, Michael
AU  - Natt, Bhupinder
AU  - Mosier, Jarrod
AU  - Malo, Joshua
AU  - Bime, Christian
TI  - The Association of Non-Cardiac ECMO With Influenza Incidence: A Time Series Analysis
AID  - 10.4187/respcare.06145
DP  - 2019 Mar 01
TA  - Respiratory Care
PG  - 279--284
VI  - 64
IP  - 3
4099  - http://rc.rcjournal.com/content/64/3/279.short
4100  - http://rc.rcjournal.com/content/64/3/279.full
AB  - BACKGROUND: The 2009 H1N1 influenza epidemic saw a rise in the use of extracorporeal membrane oxygenation (ECMO) as a supportive therapy for refractory ARDS. We sought to determine whether ECMO utilization follows a seasonal pattern that matches the influenza season, and whether it can further be explained by the incidence of each influenza subtype.METHODS: We performed a longitudinal analysis of non-cardiac and cardiac-associated ECMO cases from the National In-patient Sample from 2005 to 2014, using overdispersed Poisson regression to evaluate associations with influenza incidence categorized by influenza-like illness and total positive influenza tests divided by subtype from the Centers for Disease Control and Prevention.RESULTS: Non-cardiac ECMO use was positively associated with influenza-like illness incidence in the current month (incidence risk ratio [IRR] 1.11, 95% confidence interval [CI] 1.07–1.15, P < .001) and with influenza-like illness in the previous month (IRR 1.09, 95% CI 1.05–1.14, P < .001). The 2009 H1N1 subtype had the strongest association with non-cardiac ECMO (IRR 1.19, 95% CI 1.09–1.31, P < .001). Cardiac ECMO was also positively associated with the incidence of influenza-like illness (IRR 1.05, 95% CI 1.01–1.09, P = .02).CONCLUSION: Non-cardiac and cardiac ECMO use in the United States were significantly associated with influenza incidence. The influenza A, H1N1 2009, subtype had the strongest association.