@article {Cronly406, author = {Jennifer A Cronly and Alistair J Duff and Kristin A Riekert and Anthony P Fitzgerald and Ivan J Perry and Elaine A Lehane and Aine Horgan and Barbara A Howe and Muireann Ni Chroinin and Eileen Savage}, title = {Health-Related Quality of Life in Adolescents and Adults With Cystic Fibrosis: Physical and Mental Health Predictors}, volume = {64}, number = {4}, pages = {406--415}, year = {2019}, doi = {10.4187/respcare.06356}, publisher = {Respiratory Care}, abstract = {BACKGROUND: People with cystic fibrosis face substantial physical, psychological, and social challenges as they move into adolescence and adulthood, which are likely to impact on their health-related quality of life. This study sought to examine the relative importance of physical and mental health variables associated with health-related quality of life in this group.METHODS: Adults and adolescents (N = 174; >=14 y old) from across 11 adult or pediatric cystic fibrosis clinics in the Republic of Ireland, completed a background questionnaire that contained self-reported physical health variables, pulmonary function (ie, FEV1\%) and body mass index. Questionnaire packs also contained the Hospital Anxiety and Depression Scale (HADS) and the Cystic Fibrosis Questionnaire-Revised, which has been specifically designed to assess health-related quality of life in patients with cystic fibrosis.RESULTS: HADS depression and/or anxiety scores were negatively associated with 11 of the 12 Cystic Fibrosis Questionnaire-Revised domain scores. FEV1\% was positively associated with 8 domains when controlling for HADS anxiety but only 4 domains when controlling for HADS depression. HADS anxiety and depression scores demonstrated larger effect sizes and explained a greater proportion of the variance than pulmonary function in 8 of the 12 Cystic Fibrosis Questionnaire-Revised domain scores.CONCLUSIONS: Mental health variables, depression and anxiety, were strongly associated with health-related quality of life in subjects with cystic fibrosis and demonstrated greater effect sizes and explained a higher proportion of the variance overall than the physical health indicators, FEV1\% and body mass index, which highlighted the importance of screening for, and treating, depression and anxiety symptoms.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/64/4/406}, eprint = {https://rc.rcjournal.com/content/64/4/406.full.pdf}, journal = {Respiratory Care} }