@article {Duprezrespcare.06520, author = {Fr{\'e}d{\'e}ric Duprez and Arnaud Bruyneel and Shahram Machayekhi and Marie Droguet and Yves Bouckaert and Serge Brimioulle and Gregory Cuvelier and Gregory Reychler}, title = {The Double-Trunk Mask Improves Oxygenation During High-Flow Nasal Cannula Therapy for Acute Hypoxemic Respiratory Failure}, elocation-id = {respcare.06520}, year = {2019}, doi = {10.4187/respcare.06520}, publisher = {Respiratory Care}, abstract = {BACKGROUND: High-flow nasal cannula (HFNC) oxygen therapy is used to deliver an FIO2 from 0.21 to 1.0. The double-trunk mask (DTM) is a device designed to increase the FIO2 in patients with a high inspiratory flow demand. The aim of our study was to evaluate the effect of DTM in hypoxemic subjects already receiving HFNC.METHODS: We report a prospective multi-center crossover pilot study including 15 subjects treated with HFNC for acute hypoxemic respiratory failure. Measurements were performed at the end of 30-min periods with HFNC only, with HFNC + DTM, and again with HFNC only.RESULTS: Compared with HFNC alone, HFNC + DTM increased PaO2 from 68 {\textpm} 14 mm Hg to 85 {\textpm} 22 mm Hg (P \< .001) and did not affect PaCO2 (P = .18). In the 11 responders, the PaO2 increased from 63 {\textpm} 12 mm Hg to 88 {\textpm} 23 mm Hg (P \< .001). No complications were reported during DTM use.CONCLUSIONS: In subjects receiving oxygen via HFNC, the addition of the DTM over the HFNC increased PaO2 without changing the PaCO2.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/early/2019/04/30/respcare.06520}, eprint = {https://rc.rcjournal.com/content/early/2019/04/30/respcare.06520.full.pdf}, journal = {Respiratory Care} }