@article {Paneroni984, author = {Mara Paneroni and Enrico Clini and Carla Simonelli and Luca Bianchi and Francesca Degli Antoni and Michele Vitacca}, title = {Safety and Efficacy of Short-Term Intrapulmonary Percussive Ventilation in Patients With Bronchiectasis}, volume = {56}, number = {7}, pages = {984--988}, year = {2011}, doi = {10.4187/respcare.01098}, publisher = {Respiratory Care}, abstract = {BACKGROUND: Treatment of bronchiectasis includes drugs, oxygen therapy, and bronchial-clearance maneuvers. OBJECTIVE: To assess the safety and efficacy of intrapulmonary percussive ventilation (IPV) compared to traditional standard chest physical therapy in patients with bronchiectasis and productive cough. METHODS: In a randomized crossover study, 22 patients underwent, on consecutive days, IPV and chest physical therapy. Before each treatment session, immediately after the session, 30 min after the session, and 4 hours after the session we measured SpO2, heart rate, respiratory rate, and (with a visual analog scale) the patient{\textquoteright}s subjective sensation of phlegm encumbrance and dyspnea. Immediately after each treatment session we also measured (via visual analog scale) the patient{\textquoteright}s discomfort. We also measured the volume and wet and dry weight of collected sputum. RESULTS: No adverse effects were so severe as to require discontinuation of treatment, and the incidence of adverse effects was similar in the groups (27\%). Heart rate (P = .002) and respiratory rate (P = .047) decreased during treatment, and sensation of phlegm encumbrance improved (P = .03) with both treatments. Only IPV improved (P = .004) the sensation of dyspnea. The patients found IPV more comfortable than our traditional standard chest physical therapy (P = .03). Both treatments caused important phlegm production, but there were no differences in sputum volume, wet weight, or dry weight. CONCLUSIONS: In patients with bronchiectasis and productive cough, short-term IPV was as safe and effective as traditional chest physical therapy, with less discomfort.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/56/7/984}, eprint = {https://rc.rcjournal.com/content/56/7/984.full.pdf}, journal = {Respiratory Care} }