TY - JOUR T1 - Ultrasound Assessment of Lung Aeration in Subjects Supported by Venovenous Extracorporeal Membrane Oxygenation JF - Respiratory Care SP - 1478 LP - 1487 DO - 10.4187/respcare.06907 VL - 64 IS - 12 AU - Xiao Lu AU - Charlotte Arbelot AU - Annia Schreiber AU - Olivier Langeron AU - Antoine Monsel AU - Qin Lu Y1 - 2019/12/01 UR - http://rc.rcjournal.com/content/64/12/1478.abstract N2 - BACKGROUND: The value of ultrasound in assessing lung aeration of patients with ARDS who require venovenous extracorporeal membrane oxygenation (ECMO) has, to our knowledge, never been studied. The objective of the study was to evaluate by using ultrasound lung aeration at ECMO initiation and withdrawal in subjects with severe ARDS supported by venovenous ECMO.METHODS: Fifty subjects were included in this pilot retrospective study. The lung ultrasound aeration score (LUS) and respiratory variables were collected at ECMO initiation (T0) and ECMO withdrawal (T1). The LUS at T0 between the subjects who survived to ICU discharge and those who died in ICU was compared. The relationship between changes in LUS and changes in PaO2/FIO2 from T0 to T1 was assessed.RESULTS: The ICU mortality was 34%. The LUS at T0 did not differ between survivors and non-survivors (median 22 [interquartile range] {IQR} 19–26 vs median 24 [IQR, 19–28]; P = .60). From T0 to T1, the LUS decreased significantly in survivors (median 22 [IQR, 19–26] vs median 16 [IQR, 13–19]; P < .001), it decreased moderately in non-survivors who were weaned off ECMO (median 26 [24–29]) vs median 22 (IQR, 17–24), P = .031), and remained stable in those who died during ECMO (median 25 [IQR, 19–29] vs median 25 [IQR, 23–31]; P = .22). Changes in PaO2/FIO2 were not related to changes in the LUS between T0 and T1.CONCLUSIONS: At the time of ECMO placement, the subjects who survived ARDS had aeration loss close to that observed in the subjects who did not survive. At the time of ECMO withdrawal, there was a significant improvement in lung aeration in the survivors, whereas a severe loss of lung aeration persisted in the non-survivors, although some were weaned off ECMO. Lung ultrasound provided a valuable tool for bedside assessment of lung aeration in subjects supported by ECMO. ER -