PT  - JOURNAL ARTICLE
AU  - Weizhong Jin
AU  - Chia-Chen Chuang
AU  - Hualiang Jin
AU  - Jian Ye
AU  - Eswar Kandaswamy
AU  - Limin Wang
AU  - Li Zuo
TI  - Effects of Pre-Hospital Antiplatelet Therapy on the Incidence of ARDS
AID  - 10.4187/respcare.07177
DP  - 2020 Feb 11
TA  - Respiratory Care
PG  - respcare.07177
4099  - http://rc.rcjournal.com/content/early/2020/02/11/respcare.07177.short
4100  - http://rc.rcjournal.com/content/early/2020/02/11/respcare.07177.full
AB  - BACKGROUND: Clinical observations on the potential of pre-hospital antiplatelet therapy in preventing ARDS have been inconsistent. To further the correlation between antiplatelet therapy and ARDS, we conducted a meta-analysis to evaluate the effects of pre-hospital antiplatelet therapy on subjects with ARDS.METHODS: A literature search in major data banks was performed. We included prospective and retrospective cohorts, case-control trials, and randomized controlled trials that compared the ARDS incidence in subjects with or without pre-hospital antiplatelet agents.RESULTS: Meta-analysis of 7 studies (a total of 30,291 subjects) showed significantly lower odds of ARDS in the pre-hospital antiplatelet therapy group compared with subjects with no pre-hospital antiplatelet therapy (odds ratio 0.68, 95% CI 0.56–0.83; P < .001). However, ARDS mortalities in the hospital and ICUs were not affected.CONCLUSIONS: These findings indicated that pre-hospital antiplatelet therapy was associated with a reduced rate of ARDS but had no effect on the mortality in the subjects at high risk.