TY - JOUR T1 - Effects of Pre-Hospital Antiplatelet Therapy on the Incidence of ARDS JF - Respiratory Care DO - 10.4187/respcare.07177 SP - respcare.07177 AU - Weizhong Jin AU - Chia-Chen Chuang AU - Hualiang Jin AU - Jian Ye AU - Eswar Kandaswamy AU - Limin Wang AU - Li Zuo Y1 - 2020/02/11 UR - http://rc.rcjournal.com/content/early/2020/02/11/respcare.07177.abstract N2 - BACKGROUND: Clinical observations on the potential of pre-hospital antiplatelet therapy in preventing ARDS have been inconsistent. To further the correlation between antiplatelet therapy and ARDS, we conducted a meta-analysis to evaluate the effects of pre-hospital antiplatelet therapy on subjects with ARDS.METHODS: A literature search in major data banks was performed. We included prospective and retrospective cohorts, case-control trials, and randomized controlled trials that compared the ARDS incidence in subjects with or without pre-hospital antiplatelet agents.RESULTS: Meta-analysis of 7 studies (a total of 30,291 subjects) showed significantly lower odds of ARDS in the pre-hospital antiplatelet therapy group compared with subjects with no pre-hospital antiplatelet therapy (odds ratio 0.68, 95% CI 0.56–0.83; P < .001). However, ARDS mortalities in the hospital and ICUs were not affected.CONCLUSIONS: These findings indicated that pre-hospital antiplatelet therapy was associated with a reduced rate of ARDS but had no effect on the mortality in the subjects at high risk. ER -