TY - JOUR T1 - Effect of CPAP on Oxidative Stress and Circulating Progenitor Cell Levels in Sleep Patients With Apnea-Hypopnea Syndrome JF - Respiratory Care SP - 1830 LP - 1836 DO - 10.4187/respcare.01081 VL - 56 IS - 11 AU - Mora Murri AU - Regina García-Delgado AU - José Alcázar-Ramírez AU - Ana Fernández-Ramos AU - Juan Alcaide AU - Fernando Cardona AU - Francisco J Tinahones Y1 - 2011/11/01 UR - http://rc.rcjournal.com/content/56/11/1830.abstract N2 - BACKGROUND: The sleep apnea-hypopnea syndrome is associated with elevated oxidative stress, which is associated with reduced levels and functional impairment of progenitor cells. OBJECTIVE: To evaluate whether one month of CPAP treatment affects circulating-progenitor-cell levels and oxidative stress in patients with sleep apnea-hypopnea syndrome. METHODS: We enrolled 13 patients with sleep apnea-hypopnea syndrome who required nasal CPAP. We evaluated white-blood-cell oxidative stress and CD45−, CD34+, KDR+, and CD133+ cell levels via flow-cytometry, before and one month after CPAP treatment. RESULTS: Superoxide anion and hydrogen peroxide were reduced, and markers of protection against oxidative stress were increased after CPAP. Progenitor-cell levels increased significantly after CPAP. There was a significant negative correlation between CD45−, CD34+, KDR+, and CD133+ cell levels and the severity of sleep apnea-hypopnea syndrome and superoxide anion. CONCLUSIONS: CD45−, CD34+, KDR+, and CD133+ cell levels rose significantly and reached values close to those in the control group after one month of CPAP. This change was accompanied by a significant decrease in oxidative stress, and no change in anthropometric or metabolic variables, including insulin resistance, weight, blood pressure, or lipid levels; consequently, the increase in progenitor-cell levels might be attributable to reduced oxidative stress. ER -