TY - JOUR T1 - High-Flow Nasal Cannula vs Conventional Oxygen Therapy for Postcardiothoracic Surgery JF - Respiratory Care DO - 10.4187/respcare.07595 SP - respcare.07595 AU - Yiwei Wang AU - Dong Huang AU - Yuenan Ni AU - Zongan Liang Y1 - 2020/06/09 UR - http://rc.rcjournal.com/content/early/2020/06/09/respcare.07595.abstract N2 - BACKGROUND: High-flow nasal cannula (HFNC) oxygen therapy is widely used in extubated patients. We aim to evaluate the effect of HFNC compared with conventional oxygen therapy in adults after cardiothoracic surgery.METHODS: We conducted a literature search in PubMed, Embase, and ClinicalTrials for randomized controlled trials that compared HFNC with conventional oxygen therapy in extubated patients after cardiothoracic surgery.RESULTS: Eight studies with 1,086 subjects were included. Compared with conventional oxygen therapy, HFNC was associated with a significant reduction in the need for escalation of respiratory support (risk ratio 0.40, 95% CI 0.26–0.61, P < .001), re-intubation rate (risk ratio 0.35, 95% CI 0.13–0.96, P = .04), and length of hospital stay (mean difference –0.48, 95% CI –0.95 to –0.01, P = .05). No significant differences were found for the length of ICU stay (mean difference –0.09, 95% CI –0.21 to –0.04, P = .18), pulmonary complications (risk ratio 0.85, 95% CI 0.48–1.48, P = .56), or mortality rate (risk ratio 0.54, 95% CI 0.12–2.53, P = .44).CONCLUSIONS: HFNC may significantly reduce the need for the escalation of respiratory support and re-intubation rate, and might reduce the hospital stay. More high-quality randomized controlled trials are needed to further validate our results. ER -