PT  - JOURNAL ARTICLE
AU  - David N Matlock
AU  - Shasha Bai
AU  - Michael D Weisner
AU  - Norman Comtois
AU  - Jennifer Beck
AU  - Christer Sinderby
AU  - Sherry E Courtney
TI  - Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation
AID  - 10.4187/respcare.07257
DP  - 2020 Jul 01
TA  - Respiratory Care
PG  - 946--953
VI  - 65
IP  - 7
4099  - http://rc.rcjournal.com/content/65/7/946.short
4100  - http://rc.rcjournal.com/content/65/7/946.full
AB  - BACKGROUND: We tested whether work of breathing in premature newborns estimated by phase angle (θ) by using respiratory inductance plethysmography is decreased during neurally-adjusted ventilatory assist (NAVA) noninvasive ventilation (NIV) versus NIV alone.METHODS: NAVA NIV and NIV were applied in random order while using respiratory inductance plethysmography to measure the phase angle.RESULTS: Patient-ventilator asynchrony was decreased during NAVA NIV; however, the phase angle was not different between the modes. A large number of repeated assists with switches to backup were found when using NAVA NIV. Results of the analysis indicated these were due to the apnea alarm limit set during NAVA NIV.CONCLUSIONS: The improvement in patient-ventilator synchrony supports the hypothesis that work of breathing may be decreased with NAVA NIV; however, we were unable to demonstrate this with our study design. Short apnea time settings with NAVA NIV led to a large number of switches to backup and repeated assists during the same neural effort. (ClinicalTrials.gov registration NCT02788110.)