%0 Journal Article %A Preslee Flaugher %A Lucy Cacioppo %A Breann Landis %A Riley Wallis %A Doug Pursley %A Brandon Burk %A Aaron Light %T The Effects of Three Percussive Devices on Mucus Clearance in a Cystic Fibrosis Simulated Lung %D 2020 %J Respiratory Care %P 3442323 %V 65 %N Suppl 10 %X Background: For patients with cystic fibrosis, thick secretions cause a need for bronchial hygiene therapy. We tested three percussive devices that are designed for secretion mobilization to determine the most efficient product: The IPV (Model IPV-1C, Percussionaire, Sandpoint, ID), MetaNeb (Hill-Rom, St. Paul, MN), and Vortran PercussiveNEB (Model 2.0, Vortran Medical Technology, Sacramento, CA). Our null hypothesis is that the three devices will show no significant difference in rate of mucus velocity when compared. Methods: An ASL 5000 lung simulator (Ingmar Medical, Pittsburgh, PA) was set to simulate a cystic fibrosis patient with a Cstat of 45 cm H2O, Raw of 17 cm H2O/L/s, VT 800 mL, f 15, and I:E ratio 1:2. To create the airway, a 10 mm I.D. x 30 cm clear plexiglass tube was attached to the ASL 5000 and each device was attached to the distal end of the tube. A hole was drilled in the center of the tube to accommodate a 10 mL syringe. For the mucus simulant, two parts of Aquasonic 100 Ultrasound Transmission Gel (Parker Laboratories Inc., USA) was mixed with three parts of water. This mixture’s viscosity has been documented to be in the same range of human sputum. For each run, 1 mL of mucus simulant was injected into the center of the leveled plexiglass tube and allowed to settle for one minute. Each device was set to run for 30 seconds at the highest and lowest frequency setting for 5 trials. The best three out of the five trials were used in the mean for the conclusion. A photograph was taken at the end of each trial using a 12 megapixel camera. We set the starting point for the measurement at the distal leading edge of mucus once settled and measured the amount of forward or backward movement after the trial was completed in centimeters via ruler and pixel measurement. Results: The IPV produced forward movement of +10.67 cm on the high frequency setting and +6.12 cm on its low frequency setting. The MetaNeb’s average was - 0.02 cm on low frequency and - 0.14 cm on high frequency. The Vortran PercussiveNEB’s average on the low frequency setting was - 0.79 cm and - 16.76 cm on the high setting. Conclusions: We rejected our null hypothesis because there were significant differences between the three devices. The MetaNeb and Vortran PercussiveNEB both produced negative caudad movement on both high and low frequency settings. The IPV produced forward cephalad movement on both high and low frequency settings. During use of the IPV, secretion movement is best when set at its highest frequency. %U