RT Journal Article
SR Electronic
T1 Maximum Voluntary Ventilation and Its Relationship With Clinical Outcomes in Subjects With COPD
JF Respiratory Care
FD American Association for Respiratory Care
SP 79
OP 86
DO 10.4187/respcare.07855
VO 66
IS 1
A1 Ana Carolina Andrello
A1 Leila Donaria
A1 Larissa A de Castro
A1 Letícia F Belo
A1 Lorena P Schneider
A1 Felipe VC Machado
A1 Marcos Ribeiro
A1 Vanessa S Probst
A1 Nidia A Hernandes
A1 Fabio Pitta
YR 2021
UL http://rc.rcjournal.com/content/66/1/79.abstract
AB BACKGROUND: Previous studies have reported that maximum voluntary ventilation (MVV) may be better associated with commonly used outcomes in COPD than FEV1 and may provide information on respiratory mechanics. In this study, we aimed to investigate the relationship between MVV and clinical outcomes in COPD and to verify whether MVV predicts these outcomes better than FEV1.METHODS: We conducted a cross-sectional study involving individuals with COPD. Lung function was assessed with spirometry; maximum inspiratory and expiratory pressures (PImax and PEmax, respectively) were assessed with manuvacuometry; and functional exercise capacity was assessed with the 6-min-walk test (6MWT). Dyspnea was assessed with the modified Medical Research Council (mMRC) scale; functional status was assessed with the modified Pulmonary Functional Status and Dyspnea Questionnaire (PFSDQ-m); and health status was assessed with the COPD Assessment Test (CAT). Correlations were verified with the Spearman coefficient, and stepwise multiple linear regression models investigated the predictors of clinical outcomes.RESULTS: Our study included 157 subjects: 82 males; median (interquartile range) age 66 (61–73) y; FEV1 46 (33–57) % predicted; 6MWT 86 (76–96) % predicted; PFSDQ-m total score 34 (14–57); and CAT total score 13 (7–19). Moderate correlations were found between MVV and PImax (r = 0.40), 6MWT (r = 0.50), mMRC (r = –0.56), and total scores on the PFSDQ-m (r = –0.40) and the CAT (r = –0.54). In the regression models, MVV was a predictor of almost all clinical outcomes, unlike FEV1.CONCLUSIONS: MVV correlates moderately with clinical outcomes commonly used in the evaluation of individuals with COPD, and MVV is a better predictor of respiratory muscle strength, functional exercise capacity, and patient-reported outcomes than FEV1.