RT Journal Article
SR Electronic
T1 Corrected Minute Ventilation Is Associated With Mortality in ARDS Caused by COVID-19
JF Respiratory Care
FD American Association for Respiratory Care
SP 619
OP 625
DO 10.4187/respcare.08314
VO 66
IS 4
A1 Federica Fusina
A1 Filippo Albani
A1 Michele Bertelli
A1 Erika Cavallo
A1 Serena Crisci
A1 Rosalba Caserta
A1 Maia Nguyen
A1 Michele Grazioli
A1 Valeria Schivalocchi
A1 Antonio Rosano
A1 Giuseppe Natalini
YR 2021
UL http://rc.rcjournal.com/content/66/4/619.abstract
AB BACKGROUND: The ratio of dead space to tidal volume (VD/VT) is associated with mortality in patients with ARDS. Corrected minute ventilation () is a simple surrogate of dead space, but, despite its increasing use, its association with mortality has not been proven. The aim of our study was to assess the association between and hospital mortality. We also compared the strength of this association with that of estimated VD/VT and ventilatory ratio.METHODS: We performed a retrospective study with prospectively collected data. We evaluated 187 consecutive mechanically ventilated subjects with ARDS caused by novel coronavirus disease (COVID-19). The association between and hospital mortality was assessed in multivariable logistic models. The same was done for estimated VD/VT and ventilatory ratio.RESULTS: Mean ± SD was 11.8 ± 3.3 L/min in survivors and 14.5 ± 3.9 L/min in nonsurvivors (P < .001) and was independently associated with mortality (adjusted odds ratio 1.15, P = .01). The strength of association of with mortality was similar to that of VD/VT and ventilatory ratio.CONCLUSIONS: was independently associated with hospital mortality in subjects with ARDS caused by COVID-19. could be used at the patient’s bedside for outcome prediction and severity stratification, due to the simplicity of its calculation. These findings need to be confirmed in subjects with ARDS without viral pneumonia and when lung-protective mechanical ventilation is not rigorously applied.