PT  - JOURNAL ARTICLE
AU  - Wernly, Bernhard
AU  - Bruno, Raphael Romano
AU  - Frutos-Vivar, Fernando
AU  - Peñuelas, Oscar
AU  - Rezar, Richard
AU  - Raymondos, Konstantinos
AU  - Muriel, Alfonso
AU  - Du, Bin
AU  - Thille, Arnaud W
AU  - Ríos, Fernando
AU  - González, Marco
AU  - del-Sorbo, Lorenzo
AU  - Marín, Maria del Carmen
AU  - Pinheiro, Bruno Valle
AU  - Soares, Marco Antonio
AU  - Nin, Nicolas
AU  - Maggiore, Salvatore M
AU  - Bersten, Andrew
AU  - Kelm, Malte
AU  - Amin, Pravin
AU  - Cakar, Nahit
AU  - Young Suh, Gee
AU  - Abroug, Fekri
AU  - Jibaja, Manuel
AU  - Matamis, Dimitros
AU  - Zeggwagh, Amine Ali
AU  - Sutherasan, Yuda
AU  - Guidet, Bertrand
AU  - De Lange, Dylan W
AU  - Beil, Michael
AU  - Svri, Sigal
AU  - van Heerden, Vernon
AU  - Flaatten, Hans
AU  - Anzueto, Antonio
AU  - Osmani, Venet
AU  - Esteban, Andrés
AU  - Jung, Christian
TI  - Propensity-Adjusted Comparison of Mortality of Elderly Versus Very Elderly Ventilated Patients
AID  - 10.4187/respcare.08547
DP  - 2021 May 01
TA  - Respiratory Care
PG  - 814--821
VI  - 66
IP  - 5
4099  - http://rc.rcjournal.com/content/66/5/814.short
4100  - http://rc.rcjournal.com/content/66/5/814.full
AB  - BACKGROUND: The growing proportion of elderly intensive care patients constitutes a public health challenge. The benefit of critical care in these patients remains unclear. We compared outcomes in elderly versus very elderly subjects receiving mechanical ventilation.METHODS: In total, 5,557 mechanically ventilated subjects were included in our post hoc retrospective analysis, a subgroup of the VENTILA study. We divided the cohort into 2 subgroups on the basis of age: very elderly subjects (age ≥ 80 y; n = 1,430), and elderly subjects (age 65–79 y; n = 4,127). A propensity score on being very elderly was calculated. Evaluation of associations with 28-d mortality was done with logistic regression analysis.RESULTS: Very elderly subjects were clinically sicker as expressed by higher SAPS II scores (53 ± 18 vs 50 ± 18, P < .001), and their rates of plateau pressure < 30 cm H2O were higher, whereas other parameters did not differ. The 28-d mortality was higher in very elderly subjects (42% vs 34%, P < .001) and remained unchanged after propensity score adjustment (adjusted odds ratio 1.31 [95% CI 1.16–1.49], P < .001).CONCLUSIONS: Age was an independent and unchangeable risk factor for death in mechanically ventilated subjects. However, survival rates of very elderly subjects were > 50%. Denial of critical care based solely on age is not justified. (ClinicalTrials.gov registration NCT02731898.)