TY - JOUR T1 - Propensity-Adjusted Comparison of Mortality of Elderly Versus Very Elderly Ventilated Patients JF - Respiratory Care SP - 814 LP - 821 DO - 10.4187/respcare.08547 VL - 66 IS - 5 AU - Bernhard Wernly AU - Raphael Romano Bruno AU - Fernando Frutos-Vivar AU - Oscar Peñuelas AU - Richard Rezar AU - Konstantinos Raymondos AU - Alfonso Muriel AU - Bin Du AU - Arnaud W Thille AU - Fernando Ríos AU - Marco González AU - Lorenzo del-Sorbo AU - Maria del Carmen Marín AU - Bruno Valle Pinheiro AU - Marco Antonio Soares AU - Nicolas Nin AU - Salvatore M Maggiore AU - Andrew Bersten AU - Malte Kelm AU - Pravin Amin AU - Nahit Cakar AU - Gee Young Suh AU - Fekri Abroug AU - Manuel Jibaja AU - Dimitros Matamis AU - Amine Ali Zeggwagh AU - Yuda Sutherasan AU - Bertrand Guidet AU - Dylan W De Lange AU - Michael Beil AU - Sigal Svri AU - Vernon van Heerden AU - Hans Flaatten AU - Antonio Anzueto AU - Venet Osmani AU - Andrés Esteban AU - Christian Jung Y1 - 2021/05/01 UR - http://rc.rcjournal.com/content/66/5/814.abstract N2 - BACKGROUND: The growing proportion of elderly intensive care patients constitutes a public health challenge. The benefit of critical care in these patients remains unclear. We compared outcomes in elderly versus very elderly subjects receiving mechanical ventilation.METHODS: In total, 5,557 mechanically ventilated subjects were included in our post hoc retrospective analysis, a subgroup of the VENTILA study. We divided the cohort into 2 subgroups on the basis of age: very elderly subjects (age ≥ 80 y; n = 1,430), and elderly subjects (age 65–79 y; n = 4,127). A propensity score on being very elderly was calculated. Evaluation of associations with 28-d mortality was done with logistic regression analysis.RESULTS: Very elderly subjects were clinically sicker as expressed by higher SAPS II scores (53 ± 18 vs 50 ± 18, P < .001), and their rates of plateau pressure < 30 cm H2O were higher, whereas other parameters did not differ. The 28-d mortality was higher in very elderly subjects (42% vs 34%, P < .001) and remained unchanged after propensity score adjustment (adjusted odds ratio 1.31 [95% CI 1.16–1.49], P < .001).CONCLUSIONS: Age was an independent and unchangeable risk factor for death in mechanically ventilated subjects. However, survival rates of very elderly subjects were > 50%. Denial of critical care based solely on age is not justified. (ClinicalTrials.gov registration NCT02731898.) ER -