RT Journal Article
SR Electronic
T1 Propensity-Adjusted Comparison of Mortality of Elderly Versus Very Elderly Ventilated Patients
JF Respiratory Care
FD American Association for Respiratory Care
SP 814
OP 821
DO 10.4187/respcare.08547
VO 66
IS 5
A1 Wernly, Bernhard
A1 Bruno, Raphael Romano
A1 Frutos-Vivar, Fernando
A1 Peñuelas, Oscar
A1 Rezar, Richard
A1 Raymondos, Konstantinos
A1 Muriel, Alfonso
A1 Du, Bin
A1 Thille, Arnaud W
A1 Ríos, Fernando
A1 González, Marco
A1 del-Sorbo, Lorenzo
A1 Marín, Maria del Carmen
A1 Pinheiro, Bruno Valle
A1 Soares, Marco Antonio
A1 Nin, Nicolas
A1 Maggiore, Salvatore M
A1 Bersten, Andrew
A1 Kelm, Malte
A1 Amin, Pravin
A1 Cakar, Nahit
A1 Young Suh, Gee
A1 Abroug, Fekri
A1 Jibaja, Manuel
A1 Matamis, Dimitros
A1 Zeggwagh, Amine Ali
A1 Sutherasan, Yuda
A1 Guidet, Bertrand
A1 De Lange, Dylan W
A1 Beil, Michael
A1 Svri, Sigal
A1 van Heerden, Vernon
A1 Flaatten, Hans
A1 Anzueto, Antonio
A1 Osmani, Venet
A1 Esteban, Andrés
A1 Jung, Christian
YR 2021
UL http://rc.rcjournal.com/content/66/5/814.abstract
AB BACKGROUND: The growing proportion of elderly intensive care patients constitutes a public health challenge. The benefit of critical care in these patients remains unclear. We compared outcomes in elderly versus very elderly subjects receiving mechanical ventilation.METHODS: In total, 5,557 mechanically ventilated subjects were included in our post hoc retrospective analysis, a subgroup of the VENTILA study. We divided the cohort into 2 subgroups on the basis of age: very elderly subjects (age ≥ 80 y; n = 1,430), and elderly subjects (age 65–79 y; n = 4,127). A propensity score on being very elderly was calculated. Evaluation of associations with 28-d mortality was done with logistic regression analysis.RESULTS: Very elderly subjects were clinically sicker as expressed by higher SAPS II scores (53 ± 18 vs 50 ± 18, P < .001), and their rates of plateau pressure < 30 cm H2O were higher, whereas other parameters did not differ. The 28-d mortality was higher in very elderly subjects (42% vs 34%, P < .001) and remained unchanged after propensity score adjustment (adjusted odds ratio 1.31 [95% CI 1.16–1.49], P < .001).CONCLUSIONS: Age was an independent and unchangeable risk factor for death in mechanically ventilated subjects. However, survival rates of very elderly subjects were > 50%. Denial of critical care based solely on age is not justified. (ClinicalTrials.gov registration NCT02731898.)