PT - JOURNAL ARTICLE AU - Miller, Andrew G AU - Bartle, Renee M AU - Rehder, Kyle J TI - High-Frequency Jet Ventilation in Neonatal and Pediatric Subjects: A Narrative Review AID - 10.4187/respcare.08691 DP - 2021 May 01 TA - Respiratory Care PG - 845--856 VI - 66 IP - 5 4099 - http://rc.rcjournal.com/content/66/5/845.short 4100 - http://rc.rcjournal.com/content/66/5/845.full AB - High-frequency ventilation is commonly utilized with neonates and with children with severe respiratory failure. Both high-frequency oscillatory ventilation (HFOV) and high-frequency jet ventilation (HFJV) are used extensively in neonates. HFJV can also be used in older, larger children. The purpose of this narrative review is to discuss the physiologic principles behind HFJV, examine the evidence supporting its use in neonatal and pediatric ICUs, give meaningful guidance for clinical application, and highlight potential areas for future research.