@article {Andersen1196, author = {Tiina M Andersen and Brit Hov and Thomas Halvorsen and Ola Drange R{\o}ksund and Maria Volls{\ae}ter}, title = {Upper Airway Assessment and Responses During Mechanically Assisted Cough}, volume = {66}, number = {7}, pages = {1196--1213}, year = {2021}, doi = {10.4187/respcare.08960}, publisher = {Respiratory Care}, abstract = {When the ability to cough is impaired, secretion clearance may be assisted and augmented with mechanical insufflation-exsufflation (MI-E). In some individuals, the efficacy of MI-E may be hampered by counterproductive upper airway reactions, where the airways close in response to positive pressures. To fully utilize the therapeutic potential inherent in the MI-E technology, we need a better understanding of the pathophysiology behind these untoward reactions. There is increasing interest in monitoring and measuring upper airway responses to MI-E and how such information can be used to optimize MI-E settings. The purpose of this narrative review is to increase the theoretical understanding of the larynx as a respiratory organ, summarize the current literature in the area, and provide insight into how this knowledge can affect current clinical practice.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/66/7/1196}, eprint = {https://rc.rcjournal.com/content/66/7/1196.full.pdf}, journal = {Respiratory Care} }